39results about How to "Achieve curative effect" patented technology

The invention discloses a vascular condition detection method and a vascular condition detection apparatus based on a heart point fluctuation conduction property. The method comprises the following steps: making a flexible detection terminal attached to the outer side of the skin of cardiac muscle or vascular wall, dispersing a cardiac muscle or vascular wall detection region into a plurality of preset detection points, and through the active transmitting of ultrasonic wave and the array receiving of ultrasonic echo, implementing multi-dimension detection on point fluctuations or point pulse waves by virtue of back-end inversion; and identifying a vascular conduction property by virtue of a digital signal processing method by taking the plurality of the point fluctuations of the cardiac muscle and the plurality of the point pulse waves in some vascular detection region as multi-input and multi-output signals, decomposing the property so as to obtain a vascular conduction property of some section, and implementing characteristic comparison after characteristic extraction so as to achieve vascular condition and disease prediction and diagnosis. The apparatus comprises a plurality of flexible detection terminals having ultrasonic wave transmitting and receiving capability, a control module and a computation module, wherein transmitting and receiving integrated ultrasonic probe arrays are arranged the flexible detection terminals and the arrays are fixedly arranged on flexible circuit boards.

An absorbent wound care device comprising an absorbent element and an active agent, said absorbent element having a proximal and a distal surface, wherein the active agent is positioned on the proximal surface of the absorbent element and wherein the active agent is positioned in a zone having an exact defined area covering a central portion of the absorbent element, and wherein said area of the zone covers only a portion of the proximal surface of the absorbent layer, and a method of preparing such device.

The invention discloses a combined preparation for nanoparticle tumor diagnoses and treatment and a preparation method and an application thereof. The preparation adsorbs radioactive rare earth element lutetium ions with prussian blue nanoparticles which are good in biocompatibility and platelet membranes coat the surfaces of the nanoparticles. The prussian blue nanoparticles used in the preparation can be used for photo-acoustic imaging and generates energy through near infrared laser irradiation while monitoring a diagnoses and treatment agent in real time so as to improve the temperature tokill tumor cells for photothermal therapy. Meanwhile, the radioactive rare earth element lutetium ions also can realize SEPCT imaging and radiotherapy functions. The platelet membranes coating the surfaces of the nanoparticles can improve the recognition of tumor tissues so as to realize a function of targeting tumors. In addition, the nano diagnoses and treatment preparation is high in biosafety, good in tumor targeting property, simple in preparation method, low in cost and good in repeatability, and has wide application prospect in the field of tumor diagnoses and treatment.

The present invention relates to a Prussian blue-based intelligent pH-triggered MRI-monitored drug release synergistic nano therapeutic agent and a preparation method thereof. The nano therapeutic agent includes Prussian blue nanoparticles with mesoporous and hollow interior, and the hollow mesoporous Prussian blue KxMny[Fe(CN)6]z coated on the surface of the nanoparticle, wherein 0.05≤x≤0.3, 0.5≤y≤0.98, z=1, the nanomedicine is formed as a hollow mesoporous nanoparticle with a core-shell structure. The HMPB-Mn nano-diagnosis and treatment agent of the present invention has the functions of pH-responsive nuclear magnetic resonance imaging and pH-responsive drug release for chemotherapy at the tumor site, and combined with hyperthermia at the same time, realizing the combination of hyperthermia and chemotherapy under the guidance of nuclear magnetic resonance imaging to treat tumors.

The invention provides a targeted fluorescent anti-cancer drug and a preparation method thereof. A structural formula of the anti-cancer drug is shown as the description. The targeted fluorescent anti-cancer drug has the advantages that the anti-cancer drug is highly targeted and fluorescent, so that stability of the anti-cancer drug in vivo can be improved and use ratio of the anti-cancer drug can be increased; since an anti-cancer drug and cancer cell acting process and drug efficacy in-situ imaging evaluation are achieved, early cancer diagnosis is achieved, and further, cancer treatment efficiency is improved while side effect is reduced.

The invention concerns a method for extracting free mRNA from pleural fluid and abdominal dropsy. In the invention injecting pleural fluid and abdominal dropsy into an anticoagulation tube with natrium citricum without RNase, centrifugating, imbibing the supernatant, centrifugating again, imbibing the supernatant, adding the supernatant into Trizol LS solution, shaking at room temperature, addingchloroform, standing at room temperature, centrifugating and imbiling water phase layer to a new tube, adding isopropyl alcohol for RNA precipitation, centrifugating, washing with 75% ethanol, air-drying, adding RNase-free water, and dissolving RNA anti-transcribing with the RNA as templates using conventional technology into cDNA for preservation. The invention dissolves the problem that RNA cannot be extracted form pleural fluid and abdominal dropsy in the past. The invention can provide early treatment for cancer and other diseases. The invention has the advantages of easy operation and high reproducibility.

The invention provides a contrast medium used for glioma targeted magnetic resonance and fluorescence dual modality imaging, and a preparation method thereof. The contrast medium is composed of an acrylamide monomer, an allyl monmer containing sulfhydryl or carboxyl or amidogen, superparamagnetic iron oxide nanoparticles, a fluorochrome and lactoferrin. The preparation method comprises following steps: the acrylamide monomer and the allyl monmer containing sulfhydryl or carboxyl or amidogen are subjected to polymerization reaction so as to obtain a copolymer nanogel; the superparamagnetic iron oxide nanoparticles are added in polymerization reaction process so as to obtain a superparamagnetic copolymer nanogel; the fluorochrome and lactoferrin and combined via covalent bonds so as to obtain fluorochrome labeled lactoferrin; and the superparamagnetic copolymer nanogel and fluorochrome labeled lactoferrin are combined via covalent bonds so as to obtain the contrast medium used for glioma targeted magnetic resonance and fluorescence dual modality imaging. The contrast medium possesses characteristics such as high specificity, selectivity and contrast effect, and low toxic and side effect; and is capable of realizing dual modality imaging.

The invention relates to an oral liquid of leukotriene antagonist against allergy, inflammation, asthma that can be used as cell protecting agent, comprising at least a buffer solution and Montelukast dissolved in the buffer solution and its pharmaceutically acceptable salts. The pH of the buffer solution is between 7-11, and the buffer solution includes at least water, pharmaceutically acceptable alcohols, buffering agents and pharmaceutically acceptable additives.

The invention provides a lumbar intervertebral disc protrusion determination method and system. The determination method includes: acquiring surface electromyogram signals of a waist and a back; performing filtering treatment on the acquired surface electromyogram signals; performing feature value extraction on the filtered surface electromyogram signals; and performing comprehensive analysis on a waist muscle and a back muscle according to the acquired feature values so as to determine lumbar intervertebral disc protrusion. The lumbar intervertebral disc protrusion determination method and system are simple and practical, can perform preliminary determination on a lumbar intervertebral disc without the complex principle and complex devices; and the determination method can achieve therapeutic effect evaluation and recovery evaluation on the lumbar intervertebral disc protrusion, and the cost is low.

The invention discloses a manganese carbonate / polyamino acid compound and a preparation method thereof. The method comprises steps: A. mixing manganese salt or an aqueous solution of manganese salt with a Tris-HCl buffer to obtain a manganese precursor solution; mixing the carbonate Or the aqueous solution of carbonate, mixes with Tris-HCl buffer solution, obtains carbonate radical precursor solution; or, after mixing polyamino acid or polyamino acid aqueous solution with carbonate precursor solution, add manganese precursor solution to carry out static reaction; C, solid-liquid separation, washing, drying, to obtain manganese carbonate / polyamino acid Complex. The preparation method of the biomimetic mineralization of the invention is simple, convenient to operate, and does not require complex and expensive equipment; the prepared compound has good biocompatibility, biodegradability, and pH-responsive drug release characteristics.