The invention relates to a wide-width, high-strength, high-toughness and thick-wall X80M pipeline steel plate and a manufacturing method thereof. The steel plate is prepared from the chemical components including, by weight, 0.045%-0.08% of C, 0.20%-0.38% of Si, 1.55%-1.85% of Mn, 0.15%-0.35% of Cu, less than or equal to 0.010% of P, less than or equal to 0.015% of S, 0.04%-0.08% of Nb, 0.015%-0.028% of Ti, 0.015%-0.045% of Al, 0.25%-0.5% of Cr, 0.004%-0.006% of N, 0.032%-0.06% of V, 0.03%-0.05% of Zr, less than or equal to 0.15% of Ni, less than or equal to 0.12% of Mo, 0.0012%-0.0035% of Ca and the balance Fe and inevitable impurities. The produced steel plate has the comprehensive performance of high strength and good low-temperature toughness, and can ensure the safety of oil and gas transmission pipelines.