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Medicine for treating ischemic cerebral disease and its prepn

The technology of a drug and an extract is applied in the field of drugs for the treatment of ischemic encephalopathy, which can solve the problems of inability to fundamentally treat and have insignificant curative effect, and achieve the effects of significant curative effect, high drug purity and simple process.

Inactive Publication Date: 2007-11-14
山东春天药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Now, Western medicine is generally used for treatment, but it cannot be treated fundamentally.
There are few drugs for treating ischemic encephalopathy with traditional Chinese medicine, and the curative effect is not significant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh the following raw materials: notopterygium 8kg, chuanxiong 10kg, notoginseng 6kg, kudzu root extract 0.6kg, hawthorn leaf extract 0.8kg, ginkgo leaf extract 0.3kg.

[0024] The preparation method of the above-mentioned inventive medicine comprises the following steps,

[0025] Extract volatile oil from Notopterygium and Rhizoma Chuanxiong decoction pieces with water vapor, volatile oil is encapsulated with β-cyclodextrin to obtain β-cyclodextrin inclusion complex, and the dregs are used for later use;

[0026] Grind Panax notoginseng into coarse powder, combine with Notopterygium and Rhizoma Chuanxiong, add 10 times the amount of 60% ethanol, reflux extraction twice, each time for 2 hours, combine the extracts, recover ethanol under reduced pressure, and continue to concentrate until it is relatively dry at 80°C Thick paste with a density of 1.30-1.31, dried under reduced pressure at 60°C to form a dry paste;

[0027] Grind the dry paste into fine powder, add kud...

Embodiment 2

[0029] Weigh the following raw materials: notopterygium 10kg, chuanxiong 10kg, notoginseng 8kg, kudzu root extract 0.5kg, hawthorn leaf extract 0.3kg, ginkgo leaf extract 0.5kg.

[0030] Prepare as follows,

[0031] Notopterygium, Chuanxiong decoction pieces supercritical CO 2 Fluid extraction of volatile oil, volatile oil inclusion with β-cyclodextrin to obtain β-cyclodextrin inclusion complex, medicinal residues for later use;

[0032] Add 10 times the amount of 60% ethanol to notopterygium and chuanxiong medicinal residues, reflux extraction twice, each time for 2 hours, combine the extracts, recover ethanol under reduced pressure, and continue to concentrate to a thick paste with a relative density of 1.30-1.31 at 80°C. Dried under reduced pressure at 60°C to make Qianghuo and Chuanxiong dry paste;

[0033] Grind Panax notoginseng into coarse powder, add 10 times the amount of 60% ethanol, reflux extraction 3 times, 2 hours each time, combine the extracts, recover ethano...

Embodiment 3

[0036] Weigh the following raw materials: notopterygium 12kg, chuanxiong 8kg, notoginseng 8kg, kudzu root extract 0.6kg, hawthorn leaf extract 0.6kg, ginkgo leaf extract 0.4kg.

[0037] Prepare as follows,

[0038] Notopterygium, Chuanxiong decoction pieces supercritical CO 2 Fluid extraction of volatile oil, volatile oil inclusion with β-cyclodextrin to obtain β-cyclodextrin inclusion complex, medicinal residues for later use;

[0039] Add 10 times the amount of 60% ethanol to notopterygium and chuanxiong medicinal residues, reflux extraction twice, each time for 2 hours, combine the extracts, recover ethanol under reduced pressure, and continue to concentrate to a thick paste with a relative density of 1.30-1.31 at 80°C. Dried under reduced pressure at 60°C to make Qianghuo and Chuanxiong dry paste;

[0040] Grind Panax notoginseng into coarse powder, add 10 times the amount of 60% ethanol, reflux extraction 3 times, 2 hours each time, combine the extracts, recover ethanol...

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PUM

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Abstract

The medicine for treating ischemic cerebral disease is prepared with notopterygium, Chuanxiong rhizome, notoginseng, kudzu vine root extract, haw leaf extract, and gingko leaf extract in certain weight proportion. The preparation process includes supercritical CO2 extracting notopterygium and Chuanxiong rhizome pieces to obtain volatile oil; alcohol extracting notopterygium and Chuanxiong rhizome dregs and notoginseng and preparing the extract into dry extractum; merging the extracts and pressing into tablet. The medicine made of Chinese medicinal materials has high medicine purity, obvious curative effect, and can cure ischemic cerebral disease radically. The preparation process of the present invention has the advantages of high extraction rate, less medicine loss and simple operation.

Description

(1) Technical field [0001] The invention relates to a medicine for treating ischemic encephalopathy, in particular to a pure traditional Chinese medicine preparation for treating ischemic encephalopathy, and a preparation method of the medicine. (2) Background technology [0002] Ischemic cerebrovascular disease is characterized by high morbidity, mortality, morbidity and recurrence rate, which greatly endangers human health and is one of the three major causes of human death. Among them, ischemic cerebrovascular disease accounts for 56.6% to 80% of cerebrovascular diseases. At the same time, stroke is also one of the main causes of human disability. my country is a country with a high incidence and mortality of stroke in the world, with about 300 strokes per year. 10,000 people suffer from stroke, which is 1.5 times that of western countries. Chinese medicine has had a relatively systematic understanding of stroke since the period of "Internal Classics". After continuous imp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61K36/48A61K36/258A61K36/237A61K36/236A61K36/16A61K9/20A61P9/10
Inventor 李贵海杨书斌于宗渊苏本正
Owner 山东春天药业有限公司
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