Novel flavonoids
A technology of flavonoids and compounds, applied in the fields of sugar derivatives, digestive system, organic chemistry, etc.
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Embodiment 1
[0101] 13 kg of kiwifruit leaves were extracted three times with ethanol reflux, the amount of ethanol was 12, 10, and 8 times the weight of kiwifruit leaves, and the extraction time was 60, 45, and 30 minutes respectively. The extract was concentrated under reduced pressure and then dissolved in water. Then it was extracted with ethyl acetate and n-butanol respectively, and the extract was concentrated under reduced pressure. The n-butanol extract was separated by column chromatography to obtain new compounds 1, 2, and 3 respectively (see Figures 29, 30).
Embodiment 2
[0103] 1 kg of kiwi fruit leaves, heated and extracted three times with water, the amount of water used is 20, 15, and 12 times the weight of kiwi fruit leaves, the extraction time is 60, 45, and 30 minutes, the extraction temperature is 70°C, and the extraction solution is too large Pore adsorption resin (AB-8 2kg, Nankai University Chemical Factory, or other brands, such as D101, D4020, 860021, HP-20, etc.) can be used for adsorption, rinse with water and elute with 85% ethanol, and the eluent is decompressed The solvent is recovered to obtain a flavonoid mixture. The mixture was separated by column chromatography [silica gel column chromatography: ethyl acetate: methanol = 5: 1; ODS column chromatography: methanol: water = 1: 1] to obtain new compounds 1, 2, and 3, respectively.
Embodiment 3
[0105] 1 kg of kiwifruit leaves, extracted three times with methanol reflux, the amount of methanol was 12, 10, and 8 times the weight of kiwifruit leaves, the extraction time was 60, 45, and 30 minutes, and the extract was concentrated under reduced pressure to a certain volume Add water to dissolve, and then pass through macroporous adsorption resin (860021 2kg, Shandong Lukang Pharmaceutical Co., Ltd., or other brands, such as P101, D4020, AB-8, HP-20, etc.) for adsorption, rinse with water and use methanol After elution, the eluent is decompressed and the solvent is recovered to obtain a flavonoid mixture. The mixture was separated by column chromatography [silica gel column chromatography: ethyl acetate: methanol = 5: 1, ODS column chromatography: methanol: water = 1: 1] to obtain new compounds 1, 2, and 3, respectively.
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