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Medication for treating hypochondria and preparation method

A technology of depression and medicine, applied in the field of medicine, can solve problems such as large side effects and slow onset of action

Active Publication Date: 2008-01-16
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Before the 1980s, the understanding of the pathogenesis of depression mainly focused on the changes of some mental biochemical indicators, such as the imbalance of neurotransmitters or mediators such as norepinephrine, serotonin and dopamine in the brain, and the corresponding drug treatment also mainly For these links, such as monoamine oxidase inhibitors, serotonin reuptake inhibitors and tricyclic antidepressants, etc., but they all have the disadvantages of large side effects and slow onset to varying degrees. Therefore, both at home and abroad have strengthened the treatment of depression. Research on traditional Chinese medicine and natural medicine

Method used

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  • Medication for treating hypochondria and preparation method
  • Medication for treating hypochondria and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: the preparation of compound extract

[0050] (1) Get 1Kg red ginseng coarse powder and 1.33Kg Morinda officinalis coarse powder, 0.33Kg Shichangpu coarse powder and mix, extract three times with 6 times the amount of water (16L) to obtain the water extract, and concentrate to obtain a total of 1011g of extract F1, namely The ratio of raw materials is the water extract of red ginseng: Morinda officinalis: Shichangpu with a ratio of 3:4:1.

[0051] (2) Get 1Kg red ginseng coarse powder and 1.33Kg Morinda officinalis coarse powder, 1.67Kg Shichangpu coarse powder mix, extract three times with 6 times the amount of water (24L) to obtain the water extract, concentrate to obtain extract F2 1680g altogether, namely Red ginseng: Morinda officinalis: Shichangpu is the water extract of 3:4:5.

[0052] (3) Get 1Kg red ginseng coarse powder and 1.33Kg Morinda officinalis coarse powder, 1Kg calamus calamus coarse powder, extract three times with 6 times the amount of ...

Embodiment 2

[0055] Example 2: Preparation of effective parts of each single drug in the compound recipe

[0056] (1) Get 16Kg of red ginseng coarse powder, add 96L of 75% ethanol, reflux for 3 hours, and extract 3 times. Combine the filtrates, recover ethanol, add water to dissolve the extract, adjust the pH to 8 with 1% NaOH, filter, and elute with water, 50-75% ethanol, and 95% ethanol to collect 50-75 % ethanol eluate was concentrated and dried to obtain 1080 g of A in total, with a total yield of 6.75%. In addition, the preparation of A can also use 50% and 80% extraction of red ginseng, and other preparation steps are the same as above, and the total yields are respectively 5.12% and 5.20% (both are lower than 75% extraction).

[0057] (2) Take 15Kg of Morinda officinalis and decoct with water for 2 hours, each time with 90L of water, extract three times in total, concentrate to a density of 1.09, filter, and the filtrate is ultrafiltered by an ultrafiltration membrane with a molecu...

Embodiment 3

[0067] Embodiment 3: Preparation of effective part mixture

[0068] A (101g, equivalent to crude drug 1.5Kg), B (157g, equivalent to crude drug 2Kg), and C (30g, equivalent to crude drug 1.5Kg) prepared in Example 2 were mixed to obtain sample D (322g, equivalent to crude drug 5.5Kg) ).

[0069] Because the drug efficacy experiment shows that D (the mixture of active parts) has the best antidepressant effect, so the preparation research is carried out on D, and it is made into soft capsules, hard capsules and tablets. The preparation method of the formulation is provided below.

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Abstract

A Chinese medicine for treating the melancholia is prepared from red ginseng, Radix morindae officinalis and grass-leaved sweetflag rhizome proportionally. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound Chinese patent medicine prepared from traditional Chinese medicines for treating depression. Background technique [0002] In the contemporary society where competition is becoming increasingly fierce, people are under increasing psychological pressure, so the incidence of depression tends to increase. It is of great significance to study drugs for the treatment of depression. [0003] Before the 1980s, the understanding of the pathogenesis of depression mainly focused on the changes of some mental biochemical indicators, such as the imbalance of neurotransmitters or mediators such as norepinephrine, serotonin and dopamine in the brain, and the corresponding drug treatment also mainly For these links, such as monoamine oxidase inhibitors, serotonin reuptake inhibitors and tricyclic antidepressants, etc., but they all have the disadvantages of large side effects and slow onset t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/888A61P25/24A61K36/746A61K36/258A61K9/08
Inventor 刘菊妍杨中铎黄裕雷心心钟鸣
Owner GUANGZHOU HANFANG PHARMA