Production process for increasing TCM particle moisture-proof property

A technology of traditional Chinese medicine granules and moisture-proof performance, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and bulk transportation, etc., can solve the problems of poor stability of finished products, loss of active ingredients, and high labor intensity, and is conducive to environmental protection, The effect of preventing moisture absorption problems and improving product quality

Active Publication Date: 2008-02-13
JIUZHITANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Over the years, people have found some shortcomings of the alcohol precipitation process: such as high cost, large amount of ethanol consumption, large loss (ethanol loss is generally more than 30%), poor stability of finished products (easy to absorb moisture and agglomerate), production cycle Long, high labor intensity, serious loss of active ingredients, easy to cause environmental pollution, etc.
[0007] At present, film coating technology has not been widely used in the moisture-proof of traditional Chinese medicine granules.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (Example 1, Yiganning granule preparation process)

[0020] Prescription: The medical materials in this embodiment have 13 crude drugs, their names and dosages are: 606g of Radix Astragali, 408g of Hedyotis diffusa, 606g of Capillary, 408g of Desmodium, 490g of Codonopsis, 408g of Dandelion, 490g of Radix Polygoni Multiflori, 408g of Cortex Moutan, Danshen 490g, Poria 408g, Baishao 408g, Atractylodes macrocephala 408g, Toosendan 408g.

[0021] Preparation method: In the above thirteen herbs, decoct Astragalus with water twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.20-1.30 (relative to water, measured at 20°C Obtain) and become clear ointment stand-by; Extract volatile oil from capillary wormwood, use β-cyclodextrin (or claim beta cyclodextrin, English name: Betacvclodextrin) 290g clathrate, obtain capillary wormwood volatile oil clathrate for subsequent use; Follow the steps below:

[0022] (a) Ex...

Embodiment 2

[0027] (Example 2, preparation process of Lvjiao Buxue Granules)

[0028] Prescription: The medicinal materials in this example include 6 crude drugs, their names and dosages are: 216g donkey-hide gelatin, 180g astragalus, 180g codonopsis, 120g rehmannia glutinosa, 90g atractylodes macrocephala, and 60g angelica.

[0029] Preparation method: For the above six flavors, distill Angelica and Atractylodes Rhizoma Atractylodes Rhizome, collect the distillate for later use; then proceed as follows:

[0030] (a) Extraction of the remaining crude drugs: decoct the residues of Angelica Sinensis and Atractylodes Rhizoma Atractylodes Rhizome with astragalus, Codonopsis pilosula, and Rehmannia glutinosa with water three times, for 2.0 hours for the first time, and 1.0 hours for the second and third times, combine the decoctions, and filter to obtain the extract .

[0031] (b) Flocculate and clarify the extract, and then filter to obtain the filtrate: heat the extract to 70° C., and conce...

Embodiment 3

[0035] (Example 3, Yiganning granule preparation process)

[0036] Prescription: The medical materials in this embodiment have 13 crude drugs, their names and dosages are: 606g of Radix Astragali, 408g of Hedyotis diffusa, 606g of Capillary, 408g of Desmodium, 490g of Codonopsis, 408g of Dandelion, 490g of Radix Polygoni Multiflori, 408g of Cortex Moutan, Danshen 490g, Poria 408g, Baishao 408g, Atractylodes macrocephala 408g, Toosendan 408g.

[0037] Preparation method: the rest are the same as in Example 1, except that in step (b), the extract is heated to 90° C. and then concentrated until the ratio of the number of milliliters to the number of grams of the whole crude drug is 8:1. Adjust the pH to 4, add chitosan colloid solution with a weight percentage concentration of 1% while it is hot at 90°C, and add 1.0ml of crude drug per gram of crude drug based on the weight percentage concentration of 1% chitosan For the sugar colloid solution, the time to continue stirring was ...

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PUM

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Abstract

The present invention relates to a production process capable of raising moisture-resisting property of Chinese medicine granules. Said production process is characterized by that its adopts individual or combined application of flocculation clarification technique and film coating technique to remove moisture-absorbing component in the Chinese medicine extract and can retain effective components of said Chinese medicine, and can eliminate environmental influence due to alcohol precipitation process, so that said invention can better solve the moisture-resisting problem of Chinese medicine granules.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a production process of traditional Chinese medicine granules. Background technique [0002] In my country's traditional Chinese medicine pharmaceutical industry, the alcohol precipitation method is commonly used in the purification process of traditional Chinese medicine extracts. The traditional preparation process of traditional Chinese medicine granules is: medicinal materials (all or part of crude drugs) → extraction → pre-concentration → alcohol precipitation → post-concentration → granulation → drying → packaging → finished product. Over the years, people have found some shortcomings of the alcohol precipitation process: such as high cost, large amount of ethanol consumption, large loss (ethanol loss is generally more than 30%), poor stability of finished products (easy to absorb moisture and agglomerate), production cycle Long, high labor intensity, s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/00A61K36/74A61K36/804A61K9/16
Inventor 谢安夏新华徐学云郭建生严建业
Owner JIUZHITANG
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