Treating agent of plant poly pentene alcohol gor liver damage
A technology of polyprenol and birch polyprenol, applied in the field of liver injury therapeutic agents, can solve the problems of lack of literature and patents, and achieve the effects of improving tumor inhibition rate, increasing thymus index, and inhibiting tumor cell proliferation
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Embodiment 1
[0039] A plant polyprenol liver injury therapeutic agent used as a drug for preventing and treating alcoholic liver, fatty liver and liver cancer caused by chemical substances or toxins, using plant polyprenol as a medicinal active ingredient, the plant polyprenol Polyprenol has the birch polyprenol structure: ω-(trans) m -(cis) n -α, wherein, ω is a terminal prenyl group, trans is a trans-prenyl group, cis is a cis-prenyl group, and α is a terminal cis-prenyl alcohol or derivatives thereof (derivatives can be: polyprenol acetate or polyprenyl phosphate), m=2, n=10-22 integers, and the chemical structure of the plant polyprenol is as follows:
[0040]
[0041] Among them, n can be selected as 11, 12, 13, 14, 15, 16, 17, 18, 19, 20,
[0042] In this embodiment, the plant polyprenol can be derived from a kind of coniferous species such as ginkgo biloba, masson pine, cedar, black pine, and slash pine. In this embodiment, ginkgo leaf polyprenol or masson pine coniferous polyp...
Embodiment 2
[0054] Example 2 Phytopolyprenol (PP) has a therapeutic effect on alcoholic liver injury
[0055] Experimental animals: 50 female KM secondary mice, 18-22g
[0056] Experimental method: Dilute the plant polyprenol with vegetable oil to 4%, and give the plant polyprenol drug through i.p.
[0057] The dosage of the experimental plant polyprenol is 1-500 mg / kg b.wt / d, preferably 300, 150, 50 mg / kg b.wt / d three dosage groups. The model control group was alcohol, and the blank control group was vegetable oil. Plant polyprenol dose The test substance was prepared with soybean salad oil, and the blank control group and the model control group were given soybean salad oil, and each group was orally administered with 10 mg / kg b.wt per day for 30 consecutive days. After the administration of the test substance, the plant polyprenol sample dosage group and the model control group were given 50% ethanol 13mg / kg b.wt. by intragastric administration, which caused liver damage to the mice....
Embodiment 3
[0072] Example 3 Plant polyprenol (PP) has therapeutic and protective effect on carbon tetrachloride liver injury
[0073] Experimental animals: male ICR mice, weighing 25-28g.
[0074] Experimental method: 70 male ICR mice were randomly divided into 7 groups, 10 in each group, respectively normal group, model group, bifendate 200mg / Kg group, Yishanfu 711mg / Kg group, plant polypentene The experimental dose of alcohol sample is 1-500mg / kg b.wt / d, preferably plant polyprenol 10mg / Kg low dose group, plant polyprenol 40mg / Kg medium dose group, plant polyprenol 150mg / Kg high The dosage group, the normal group and the model group were intragastrically administered with normal saline containing 0.1% Tween-80, and the other groups were intragastrically administered with various drugs prepared with corresponding solvents. Continuous administration for 7 days, once a day. One hour after administration on the seventh day, all groups except the normal group were intraperitoneally inject...
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