Method for preparing carrier of hollow microsphere for medication in use for treating gastrointestinal tract
A gastrointestinal tract, hollow technology, applied in the field of preparation of hollow microsphere carrier, can solve the problems of cumbersome operation, low drug encapsulation rate, and few applications
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Embodiment approach 1
[0035] Dissolve 0.6g ethyl cellulose 10 centipoise (EC10cp) in the mixed solvent that 6.0ml ethanol and 1.0ml ether are prepared, make the mixed solution that concentration is 8.6% (g / ml) as dispersed phase, keep this dispersion The temperature of the phase is 25°C; another 50ml of liquid paraffin is added and added to 0.75g Span-80, stirred evenly and then kept at 25°C as the continuous phase, with a concentration of 1.5% (g / ml); the dispersed phase is slowly added to the continuous phase, and Stir at 300rpm / min until ethanol and ether are completely volatilized, while maintaining the temperature of the entire reaction process at 25°C; filter the solid under reduced pressure, wash the solid with 10ml of n-hexane, and dry the solid at room temperature under vacuum. A hollow microsphere carrier is obtained. The in vitro floating test proves that the hollow microspheres can sustainably float for 48 hours in the artificial gastric juice.
Embodiment approach 2
[0037]Ethanol and ether are formulated into a mixed solvent at a volume ratio of 20:1, and ethyl cellulose 100 centipoise (EC100cp) is added to make a mixed solution with a concentration of 29% (g / ml) as a dispersed phase, and the temperature of the dispersed phase is kept 40°C; add Span-85 into corn oil and stir evenly, then keep warm at 38°C as the continuous phase, the concentration of Span-85 in corn oil is 2% (g / ml); slowly add 1 volume of dispersed phase to 10 volumes in the continuous phase, and stirred at a speed of 1200rpm / min until the ethanol and ether were completely volatilized, while maintaining the temperature of the entire reaction process at 40°C; the solid was obtained by suction filtration under reduced pressure, washed with n-hexane, and the solid was placed in a vacuum Dry at room temperature to obtain the hollow microsphere carrier. The in vitro floating test proves that the hollow microspheres can sustainably float for 48 hours in the artificial gastric ...
Embodiment approach 3
[0039] Prepare ethanol and ether at a volume ratio of 2:1 to make a mixed solvent, add ethyl cellulose 20 centipoise (EC20cp) and ethyl cellulose 45 centipoise (EC45cp) to make a mixed solvent with a concentration of 5% (g / ml) The solution is used as the dispersed phase, and the temperature of the dispersed phase is kept at 20°C; the Span-60 is added into the soybean oil and stirred evenly, and then kept at 22°C as the continuous phase, and the concentration of the Span-60 in the soybean oil is 0.1% (g / ml ); slowly add 1 volume of dispersed phase into 5 volumes of continuous phase, and stir at a speed of 500rpm / min until ethanol and ether are completely volatilized, while maintaining the temperature of the entire reaction process at 20°C; vacuum filtration to obtain a solid, and use n-hexane Wash the obtained solid, and dry the solid at room temperature under vacuum to obtain a hollow microsphere carrier. The in vitro floating test proves that the hollow microspheres can susta...
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