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Preparation method of suspending stabilized scattering nano Fe3O4

A technology with stable suspension and fe3o4, applied in ferrous oxides, ferric oxides/ferric hydroxides, etc., can solve problems such as limitations and inability to produce expected effects, and achieve the effect of simple preparation method and pure product

Inactive Publication Date: 2009-05-27
YANGZHOU UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, it is limited in practical application and cannot produce the expected effect

Method used

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  • Preparation method of suspending stabilized scattering nano Fe3O4
  • Preparation method of suspending stabilized scattering nano Fe3O4
  • Preparation method of suspending stabilized scattering nano Fe3O4

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Experimental program
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Embodiment Construction

[0018] specific implementation plan

[0019] Preparation of Fe 3 o 4 particle:

[0020] Weigh 2mmolFeCl 3 and 1 mmol FeCl 2 , put it in a three-necked flask, add 4ml of deoxygenated water, and stir magnetically under the protection of nitrogen until it is completely dissolved; at room temperature, add 6ml of 2mol / L ammonia solution dropwise to the above solution at a stirring rate of 200r / min; dropwise add After completion, continue to stir for 0.5h; then, precipitate under the action of an external magnetic field, wash the particles with deoxygenated water, repeat the process of precipitation and washing until the supernatant is neutral; freeze-dry to obtain powdery black Fe 3 o 4 particle.

[0021] N-Succinyl Chitosan Derivatives Modified Fe 3 o 4 particle:

[0022] First, prepare 0.1-2.5 mg / mL aqueous solution of N-succinic diacyl chitosan derivatives, and freeze-dried Fe 3 o 4 The powder was dispersed in 25mL N-succinic diacyl chitosan derivative solution and st...

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Abstract

The invention discloses a preparing method of float stable disperse nanometer Fe3O4, which comprises the following steps: making natural macromolecular derivant as surface modifier; washing nanometer Fe3O4; freezing; drying; getting black powder form particle; putting into N-disuccinyl chitose derivant solution; stirring under room temperature; getting floating system of modified Fe3O4 particle; depositing and washing modified Fe3O4 particle under function of foreign field; freezing; drying; getting powder form modified Fe3O4 particle; dispersing into water; getting the product. This product laid the groundwork for wide biological medicine utility of Fe3O4 particle, which possesses simply method.

Description

technical field [0001] The present invention relates to a kind of nano Fe 3 o 4 , especially relates to a kind of using natural polymer derivatives as surface modifiers to prepare suspended and stable dispersed nano-Fe 3 o 4 Methods. Background technique [0002] Prior to the present invention, monodisperse magnetic nanoparticles, especially Fe 3 o 4 Particles, with biocompatibility, superparamagnetism, and nanoparticle surface effects, make them have broad application prospects in the field of biomedicine, such as nuclear magnetic resonance contrast agents, cell separation, protein separation, and magnetically targeted release carriers for anti-tumor drugs Wait. Existing methods are Fe prepared by different physical and chemical methods 3 o 4 Particles tend to aggregate and lack a biocompatible protective layer on the surface to prevent rapid absorption by the reticuloendothelial system. Therefore, it is limited in practical application and cannot produce expected ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G49/08
Inventor 朱爱萍袁兰花
Owner YANGZHOU UNIV