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Slowly releasing allopurinol tablet and its prepn

A sustained-release tablet and allopurinol technology, which is applied in the field of allopurinol sustained-release tablet and its preparation, can solve the problems of inability to maintain anti-gout blood drug concentration, and achieve the effect of stable and effective blood drug concentration

Active Publication Date: 2009-06-17
HAINAN PULIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After oral administration, allopurinol is completely absorbed in the gastrointestinal tract, and the peak plasma concentration can be reached in 2-6 hours, with a half-life of 1-3 hours. This product is metabolized into active oxypurinol in the liver, with a half-life of 15 hours. -18 hours, the current market is generally conventional tablets, generally need to take 1-2 times a day, and can not maintain a stable and effective blood concentration of anti-gout

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: This embodiment prepares 1000 allopurinol sustained-release tablets, using the following raw materials:

[0017] Allopurinol 250.0g

[0018] Xylitol 145g

[0019] Starch 50.0g

[0020] Hydroxypropyl Methyl Cellulose 35g

[0021] Povidone 15.0g

[0022] Magnesium Stearate 5.0g

[0023] Process: crush the raw materials and pass through a 100-mesh sieve, weigh allopurinol, starch, xylitol and hydroxypropyl methylcellulose according to the prescription amount, and mix them evenly; use 10% povidone alcohol solution to prepare the mixed materials Uniform soft material, granulated through 18-mesh sieve; wet granules were dried at 55°C-60°C, granulated with 18-mesh sieve, added the remaining hydroxypropyl methylcellulose, xylitol, magnesium stearate, and mixed well ;According to the determined range of tablet weight, it can be obtained by pressing tablets.

[0024] The dissolution rate of the sustained-release tablet obtained in the present embodiment is mea...

Embodiment 2

[0028] Embodiment 2: This embodiment prepares 1000 allopurinol sustained-release tablets, using the following raw materials:

[0029] Allopurinol 250g

[0030] Mannitol 120g

[0031] Starch 75g

[0032] Hypromellose 35g

[0033] Povidone 15g

[0034] Magnesium Stearate 5.0g

[0035] The preparation process is the same as the preparation method of the examples.

Embodiment 3

[0036] Embodiment 3: This embodiment prepares 1000 allopurinol sustained-release tablets, using the following raw materials:

[0037] Allopurinol 250g

[0038] Mannitol 120g

[0039] Starch 90g

[0040] Sodium Alginate 20g

[0041] Povidone 15g

[0042] Magnesium Stearate 5.0g

[0043] The preparation method is the same as in Example 1.

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PUM

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Abstract

The present invention relates to medicine form, and is especially slowly releasing allopurinol tablet and its preparation process. The slowly releasing allopurinol tablet includes allopurinol as main medicine component 10-70 wt%, slowly releasing skeleton matrix 1-15 wt%, soluble diluent 25-85 wt% and adhesive 1-10 wt%. The slowly releasing allopurinol tablet needs to be taken once a day and provides the patient with certain dependence to maintain smooth blood medicine concentration.

Description

technical field [0001] The invention relates to a dosage form of medicine, in particular to an allopurinol sustained-release tablet and a preparation method thereof. Background technique [0002] Allopurinol is a xanthine oxidase inhibitor. By inhibiting the activity of xanthine oxidase, it can reduce the synthesis of uric acid from hypoxanthine and xanthine, and reduce the concentration of uric acid in blood and urine. It has entered the National Essential Drug List and is the first-line drug for the treatment of gout. The United States Pharmacopoeia, European Pharmacopoeia, British Pharmacopoeia, etc. have all been included, and the second volume of the Chinese Pharmacopoeia 2000 edition has also been included. After oral administration, allopurinol is completely absorbed in the gastrointestinal tract, and the peak plasma concentration can be reached in 2-6 hours, with a half-life of 1-3 hours. This product is metabolized into active oxypurinol in the liver, with a half-l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/52A61K9/22A61P19/06
Inventor 范敏华
Owner HAINAN PULIN PHARMA