Modified smectite and method for producing the same and its application

A montmorillonite and modified technology, which is applied in chemical instruments and methods, pharmaceutical formulas, inorganic active ingredients, etc., can solve the problems of no treatment for chronic atrophic gastritis and no treatment for chronic atrophic gastritis reversal

Active Publication Date: 2009-07-15
ZHEJIANG HAILISHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no treatment that can effectively block chronic atrophic gastritis, let alone a treatment that can reverse chronic atrophic gastritis.

Method used

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  • Modified smectite and method for producing the same and its application
  • Modified smectite and method for producing the same and its application
  • Modified smectite and method for producing the same and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0248] Example 1 Preparation of modified montmorillonite

[0249] Phase analysis of purified montmorillonite, see figure 1 .

[0250] In purifying montmorillonite, add 2mol / L mixed acid, the composition of mixed acid is (the molar ratio of hydrochloric acid: oxalic acid: acetic acid is 4:10:6), mix with soil: the mass ratio of acid is 1:3 , boiled at 100°C for 5-6 hours, filtered to remove the mixed acid, washed the filter cake with deionized water to pH≧4, dried at 100°C, and crushed into 300-500 meshes to obtain the modified calcium-based montmorillonite Delithification, its abundance or phase analysis see figure 2 .

[0251] Prepare the obtained modified calcium-based montmorillonite with 0.5N hydrochloric acid solution to make a slurry with a solid content of 20%, stir for 6 hours, filter to remove the acid solution, wash the filter cake with hot water at 60°C until the pH is about 5, press Filter into a filter cake with a solid content of about 50%, add sodium car...

Embodiment 2

[0252] Example 2 Preparation of modified montmorillonite

[0253] Phase analysis of purified montmorillonite, see Figure 4 .

[0254] In the purification of montmorillonite, add a mixed acid with a concentration of 1mol / L, the composition of the mixed acid is (the molar ratio of hydrochloric acid: oxalic acid: acetic acid is 3:4:3), and the mass ratio of soil: acid is 1:4. Mix, boil at 90°C for 6-8 hours, filter to remove the mixed acid, wash the filter cake with deionized water to pH≧4, dry at 120°C, and grind it into 300-500 mesh to obtain the modified calcium base Montmorillonite, its abundance or phase analysis see Figure 5 .

[0255] The obtained modified calcium-based montmorillonite was mixed with 0.5N sulfuric acid solution to make a slurry with a solid content of 15%, stirred for 6 hours, filtered to remove the acid solution, and the filter cake was washed with hot water at 70°C until the pH was about 5.5. Pressure filtration into a filter cake with a solid c...

Embodiment 3

[0256] Example 3 Preparation of modified montmorillonite

[0257] Mineral composition of raw bentonite: see Figure 7 .

[0258] The raw ore is dried, crushed, passed through a 50-mesh sieve, added water and 0.3% sodium hexametaphosphate of raw ore powder to form a slurry with a solid content of 20%, stirred for two hours, passed through a three-stage hydrocyclone, and separated and removed Coarse sand can be separated into slurry; the separated slurry is adjusted to a thin slurry with a solid content of 3% by adding water, which is separated into a disc centrifuge, and the separated thin slurry is then concentrated in another disc centrifuge, and the concentrated slurry is passed through Plate and frame filter press to obtain a filter cake with a solid content of 40-50%. The filter cake is dried at 125°C and crushed to a size above 500 mesh. For the mineral composition of purified montmorillonite, see Figure 8 .

[0259] In purifying montmorillonite, add the mixed acid...

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Abstract

The invention relates to an inorganic medicine, in particular to a modified montmorillonite, a preparation method thereof and an application thereof. The modified montmorillonite refers to not destroying the dioctahedral layer structure of the natural montmorillonite and not changing its basic chemical composition, but reducing the thickness of the stacked layer by changing the microstructure formed by stacking the dioctahedral layers, Expose and increase the end-face charge and interlayer charge of montmorillonite, giving it a lower degree of C-axis order. Thereby, the existing medical use of montmorillonite is greatly strengthened, especially the reverse therapeutic effect on chronic atrophic gastritis. The invention also discloses a pharmaceutical composition containing the modified montmorillonite and the reverse therapeutic effect of the natural montmorillonite on chronic atrophic gastritis.

Description

technical field [0001] The invention relates to an inorganic medicine, in particular to a modified montmorillonite, a modified sodium-based montmorillonite, a preparation method thereof and an application thereof. Background technique [0002] Chronic atrophic gastritis (CAG) is a common and stubborn digestive system disease, the incidence rate in the general population can reach 7.5-13.8%, and there are about 150 million chronic atrophic gastritis in China patient. CAG is also recognized as a precancerous lesion of the stomach, and its cancer rate is as high as about 10%, especially significantly related to the incidence of intestinal type gastric cancer. prevention. [0003] The etiology of CAG is complex, and Helicobacter pylori (HP), bile, alcoholism and non-steroidal anti-inflammatory drugs are common pathogenic factors. Chinese medicine classifies CAG into the categories of "epigastric pain", "noisy" and "fullness". It is usually divided into three types: spleen def...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B33/40B01J20/12A61K33/00C09C1/42C09C3/08A61K8/19
Inventor 吕光烈郑海辉胡秀荣夏志国陈绩馨
Owner ZHEJIANG HAILISHENG PHARM CO LTD
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