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Gynecologyical Desheng fast dispersion solid preparation and its preparation method

A solid preparation and rapid technology, which is applied in the direction of medical preparations containing active ingredients, pill delivery, and pharmaceutical formulations, etc., can solve the problems of outdated preparation technology and inconvenient use, and achieve convenience in taking, increasing dispersion, and improving bioavailability Effect

Inactive Publication Date: 2009-07-22
JIANGXI HUIREN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Fuke Desheng Pills are already on the market in China, but in practice, the disadvantages of Fuke Desheng Pills are that the preparation process is outdated, and the dosage form is honeyed water pills, which is inconvenient to use and brings many problems to the elderly, young and patients with dysphagia. trouble

Method used

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  • Gynecologyical Desheng fast dispersion solid preparation and its preparation method
  • Gynecologyical Desheng fast dispersion solid preparation and its preparation method
  • Gynecologyical Desheng fast dispersion solid preparation and its preparation method

Examples

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Effect test

Embodiment 1

[0041] Motherwort 960g, Radix Paeoniae Alba 240g, Angelica 240g, Notopterygium 60g, Bupleurum 60g, Woody Fragrance 60g, the above six flavors, crushed into fine powder, sieved, mixed, superfinely pulverized, 400 meshes, mixed with auxiliary materials per 100 parts of powder Evenly, press the powder into large tablets (3g), and coat it with Neofil coating material. This product is a dispersible tablet, 1 tablet at a time, put into about 150-200ml of water and disintegrate into a uniform solution before taking; 2 times a day. The preparation prescription is shown in Table 1:

[0042] Table 1 Preparation prescription and its main evaluation results

[0043]

[0044] Note: (1) The amount of the main drug is 100 parts, and the amount of other excipients is the relative amount, the number of parts. (2) Others are flavoring agents and the like. (the same below)

Embodiment 2

[0046] Motherwort 960g, Paeoniae Alba 240g, Angelica 240g, Notopterygium 60g, Bupleurum 60g, Woody Fragrance 60g, the above six flavors, add water and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and filtrate Concentrate and dry, pulverize into fine powder, sieve, superfine pulverize, and pass through 300 meshes; every 100 parts of powder is mixed evenly with auxiliary materials, granulated and pressed into large tablets (15g) to obtain. This product is buccal tablet, taken orally, 1 tablet at a time, 1-2 times a day; or 1-2 tablets at a time, disintegrated in about 150-200ml of water and taken, 1-2 times a day. The preparation prescription is shown in Table 2:

[0047] Table 2 Preparation prescription and its main evaluation results

[0048]

Embodiment 3

[0050] Motherwort 960g, Paeoniae Alba 240g, Angelica 240g, Notopterygium 60g, Bupleurum 60g, Woody Fragrance 60g, and the above six flavors, the volatile oil was extracted by steam method until complete, and the volatile oil was mixed with β-CD8 times the amount of water for 30 minutes. Dry the product at low temperature, crush it to a fine powder for later use; extract the oil and water liquid and filter for later use; add water to the dregs to 8 times the amount, decoct for 2 hours, filter, combine the water and liquid twice, filter, and concentrate the filtrate to a relative density of 1.30 ~1.35 (60°C) thick paste, dried, crushed into fine powder, sieved, superfinely pulverized, passed through 300 meshes; every 100 parts of powder, mixed with auxiliary materials and volatile oil inclusion compound, pressed into large tablets (2g after granulation) ), that is. This product is taken orally, 1 tablet at a time, or taken as a uniform solution after disintegrating into about 15...

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Abstract

The invention relates to a fast-dispersing solid preparation of Fuke Desheng, which is prepared from the following traditional Chinese medicine raw materials in the weight ratio: 960 parts of Motherwort, 240 parts of Radix Paeoniae Alba, 240 parts of Angelica sinensis, 60 parts of Notopterygium, 60 parts of Bupleurum, and 60 parts of Muxiang , it is characterized in that, the fast dispersing solid preparation is after pulverizing or extracting the above-mentioned traditional Chinese medicine, and then performing ultrafine pulverization to obtain the main drug, which is selected from disintegrants, binders, suspending agents, flow aids, The auxiliary materials of the flavoring agent and the color correcting agent are mixed, and the preparation is prepared by the conventional technology of pharmacy, wherein the particle size of all the main ingredients and auxiliary materials used is less than 75 μm.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a fast-dispersing solid preparation and a preparation method thereof of the traditional Chinese medicine Fuke Desheng. technical background [0002] Fuke Desheng Pills are commonly used traditional Chinese medicines recorded in the "Standards of Chinese Patent Medicines of the Ministry of Health". Effective for liver depression, irregular menstruation caused by stagnation of qi and blood, abdominal pain during menstruation, chest fullness and rib pain, body fever in the afternoon, fatigue and lack of food. Currently in the "Ministry of Health Chinese Patent Standards" (volume 09, standard number WS3-B-1743-94) the prescription and preparation method are as follows: [0003] [Prescription and Preparation] Motherwort 960g, Paeoniae Alba 240g, Angelica 240g, Notopterygium 60g, Bupleurum 60g, Woody Fragrance 60g, the above six flavors, crushed into fine powder, sieved, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/71A61K36/533A61K36/285A61K36/237A61K36/233A61K36/232A61P15/00
Inventor 耿炤杨明宋浩亮蔡金娜梅玲华
Owner JIANGXI HUIREN PHARMA CO LTD