Production method of racemiation3-hydroxy-3- (2-phenylethyl) hexanoic acid C1-6 alkyl ester
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SUMITOMO CHEM CO LTD
- Publication Date
- 2009-08-19
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to (R)-3-hydroxyl-3-(2-phenylethyl)hexanoic acid which is a useful synthetic intermediate of anti-HIV (AIDS virus) agent and a production method of the intermediate. Background technique
[0002] PNU-140690 represented by the following formula (I) is known to be useful as an anti-HIV agent being developed in recent years. As a useful synthetic intermediate of PNU-140690, 3-hydroxy-3-(2-phenylethyl)hexanoic acid represented by the following formula (II) is known.
[0003]
[0004] The 3-hydroxy-3-(2-phenylethyl)hexanoic acid has an asymmetric carbon atom and includes (R) isomer and (S) isomer, and only the racemic compound (exo rac 3-hydroxy-3-(2-phenylethyl)hexanoic acid). Among these, the (R) isomer of the following formula (III) [(R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid] is preferably used as the above-mentioned synthetic intermediate.
[0005]
[0006] In terms of the method for the optical resolution of (R...