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Drop pills of healthy energy of wrinkled gianthyssop

A technology of Huoxiangzhengqi dripping pills and patchouli oil, applied in pill delivery, plant raw materials, digestive system, etc., can solve the problems of low natural degree, low natural degree, and low pure natural degree of dripping pill auxiliary materials, and achieve Reduce the irritating smell of drugs, improve the pH of the mouth, and have a high degree of pure natural effect

Inactive Publication Date: 2009-12-02
TIANJIN TASLY PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] With the global expansion of the market and the requirement of human beings to return to nature, the use of drugs with low toxicity and side effects, especially pure natural drugs, has become the first choice of people. The dropping pill preparation is a new type of Chinese medicine preparation with high efficiency and quick effect. The shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the current drop pill preparations generally face the following problems: 1. The drop pill auxiliary materials are not purely natural: at present, most of the drop pill base auxiliary materials are chemically synthesized, and the natural degree is low. New alternatives The search for matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, is also very difficult, because the preparation conditions required for common and possible substitutes for natural matrix excipients are very harsh. And its dripping pill dripping conditions are the key to affect the preparation of dripping pills
If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work
2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market, and has become a stumbling block for Chinese medicine to enter the international market. Therefore, looking for One or more new matrix excipients that can be accepted by the international market are particularly important and urgent
3. Disadvantages of mouthfeel and speed of onset of action: Poor taste of traditional Chinese medicine and its preparations is one of its major characteristics. When people take certain medicines, they are far more afraid of the bad taste of the medicine than they are of the disease. What's more, some patients give up the treatment of traditional Chinese medicine because they can't overcome the bad taste or smell of traditional Chinese medicine or its preparations. For example, making the medicine into capsules or sugar-coated tablets can improve the taste and reduce stimulation, but the disintegration speed is prolonged. , which is not conducive to the rapid onset of the drug, and is not suitable for some diseases, especially those that require the rapid onset of the drug
4. Difficult preparation process for industrial production of dripping pills: In the replacement process of dripping pill preparation auxiliary materials, it is very difficult to determine the preparation process for industrial production, such as the melting temperature of matrix auxiliary materials, dripping temperature, auxiliary materials and The ratio of the drug, the ratio of the caliber of the dropper, and the condensing agent are all factors that affect the drop pills. Therefore, it is time-consuming and expensive to replace the matrix and be suitable for industrial production.
[0007] In order to change the long-term situation that the base excipients of drop pills are mainly chemically synthesized excipients, and solve the problem that the base of drop pills is currently facing a low level of naturalness, it is increasingly unable to meet people's requirements for returning to nature, taking pure natural medicines with low toxicity and no side effects It can also solve some problems encountered in the export process of Chinese medicine preparations, especially dripping pill preparations, and enhance the competitiveness of the international market; the present invention has invented a toxic and side effect through a large number of experiments and research on preparation technology. Pure Chinese medicine dripping pill preparation with low cost, significant curative effect, moderate price, and suitable for industrialized large-scale production

Method used

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  • Drop pills of healthy energy of wrinkled gianthyssop
  • Drop pills of healthy energy of wrinkled gianthyssop
  • Drop pills of healthy energy of wrinkled gianthyssop

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1: the preparation of pharmaceutical active ingredient of the present invention

[0069] Take Atractylodes 160g, Chenpi 160g, Magnolia officinalis (Ginger) 160g, Angelica dahurica 240g, Poria cocos 240g, Dabupi 240g, Raw pinellia 160g, Dried ginger 13.5g, Licorice extract 20g, Patchouli oil 1.6ml according to the prescribed dosage in Pharmacopoeia , Perilla leaf oil 0.8ml for later use:

[0070]Atractylodes atractylodes, tangerine peel, Magnolia officinalis, Angelica dahurica respectively according to the percolation method under Chinese Pharmacopoeia 1995 edition one appendix I 0 liquid extract and extract, use 60% ethanol as solvent, carry out percolation after soaking for 24 hours, collect percolation liquid, recover ethanol, and prepare the medicinal liquid; after poaching poria cocos, soak at 80°C for 2 hours, the first time for 3 hours, and the second time for 2 hours, and take the juice; raw pinellia soaked in cold water, changing the water every 8 hou...

Embodiment 2

[0072] Get 833g of xylitol and 167g of dextrin and mix evenly, add 50g of the active ingredient of the present invention prepared according to the method of Example 1, heat and melt the mixture at 64°C, stir evenly, the stirring time is 10-30 minutes, keep warm, and heat at 64°C Dropping at high temperature, the diameter of the dropper is 1.2-2.5mm, drop into the methyl silicone oil at 0°C, and make 1050g pellets, drain the formed pellets and wipe off the cooling liquid, and pack them after drying, that is, have to.

Embodiment 3

[0074] Take Atractylodes 160g, Chenpi 160g, Magnolia officinalis (Ginger) 160g, Angelica dahurica 240g, Poria cocos 240g, Dabupi 240g, Raw pinellia 160g, Dried ginger 13.5g, Licorice extract 20g, Patchouli oil 1.6ml according to the prescribed dosage in Pharmacopoeia , perilla leaf oil 0.8ml standby; Atractylodes atractylodes, tangerine peel, Magnolia officinalis officinale, Angelica dahurica respectively according to the percolation method under Chinese Pharmacopoeia 1995 edition one appendix I0 liquid extract and extract item, with 60% ethanol as solvent, impregnate 24 Carry out percolation after 1 hour, collect the percolation liquid, recover ethanol, and prepare the liquid medicine for later use; after poaching poria cocos, soak at 80°C for 2 hours, take the juice for the first time for 3 hours, and the second time for 2 hours; use cold water for raw pinellia Soak, change the water every 8 hours, soak until the heart is clear, add 13.5g of dried ginger, add water and boil t...

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Abstract

A dripping pill of Chniese medicnie 'Huoxiang Zhengq pill' for treating cold, emesis, diarrhea, heat sroke and cholera is disclosed. Its advantages are high safety and lower toxic by-effect.

Description

technical field [0001] The invention relates to a preparation of dripping pills prepared from extracts of traditional Chinese medicinal plants, specifically a preparation method of Huoxiangzhengqi dropping pills and an application thereof. Background technique [0002] The prescription of Huoxiang Zhengqi comes from Huoxiang Zhengqi Powder contained in "Taiping Huimin Hejiju Prescription Volume 2". Tangerine peel, Platycodon grandiflora, and licorice, this prescription has the effect of relieving the exterior, harmonizing the middle, and aromatizing the turbidity. It is mainly used for exogenous wind and cold, internal stagnation of dampness or feeling of heat dampness, external symptoms such as cold and heat headache, and internal chest and abdomen fullness. Anorexia, vomiting, nausea, abdominal pain and diarrhea, pale mouth with greasy coating, moist and slow pulse and other symptoms of damp resistance. This prescription is often used for those with the above syndromes su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/889A61K36/8888A61K36/752A61K36/575A61K36/535A61K36/53A61K36/484A61K36/284A61K36/232A61K36/076A61P1/12A61P1/14A61P29/00
CPCY02A50/30
Inventor 童玉新顾菲菲陈亮叶寿山孙延林叶正良陈建明祝国光朱永宏郑永锋李永强李旭章顺楠刘金平魏峰
Owner TIANJIN TASLY PHARMA CO LTD
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