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Magnetic slow releasing diclofenac sodium preparation in supermolecular intercalation structure and its preparation method

A technology of diclofenac sodium and supramolecular intercalation, applied in the direction of organic active ingredients, medical preparations containing active ingredients, pharmaceutical formulations, etc., to achieve the effects of enhancing stability, improving bioavailability, and improving dispersibility

Inactive Publication Date: 2010-01-20
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no report on the sustained-release dosage form of diclofenac sodium based on magnetic supramolecular intercalation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Magnetic core MgFe 2 o 4 Preparation of Nanopowder

[0037] Weigh 5.128g (0.02Mol) Mg (NO 3 ) 2 ·6H 2 O, 4.04g (0.01Mol) Fe(NO 3 ) 3 9H 2 O and 1.99g (0.01Mol) FeCl 2 4H 2 O was dissolved in 100ml water to make a mixed salt solution, and 6g (0.15Mol) NaOH and 7.42g (0.07Mol) NaOH were weighed 2 CO 3 Dissolve in 100ml of water to make a mixed alkaline solution; drop the alkaline solution into the mixed salt solution until the pH value is 11, crystallize in a water bath at 40°C for 10 hours, filter the reaction solution with suction, wash, and then wash with absolute ethanol Washing, vacuum drying, grinding into powder, and then roasting at 800°C in an air atmosphere for 8 hours with a heating rate of 10°C / min to obtain the magnetic core MgFe 2 o 4 . Sieve with a standard sieve to obtain a relatively uniform powder. The water used in the process is decarbonized deionized water.

[0038] (2) Preparation of magnetic diclofenac sodium intercalated magnesiu...

Embodiment 2

[0042] (1) Magnetic core MgFe 2 o 4 Preparation of Nanopowder

[0043] Weigh 5.128g (0.02Mol) Mg (NO 3 ) 2 ·6H 2 O, 4.04g (0.01Mol) Fe(NO 3 ) 3 9H 2 O and 1.99g (0.01Mol) FeCl 2 4H 2 O was dissolved in 100ml water to make a mixed salt solution, and 6g (0.15Mol) NaOH and 7.42g (0.07Mol) NaOH were weighed 2 CO 3 Dissolve in 100ml of water to make a mixed alkaline solution; drop the alkaline solution into the mixed salt solution until the pH value is 11, crystallize in a water bath at 40°C for 10 hours, filter the reaction solution with suction, wash, and then wash with absolute ethanol Washing, vacuum drying, grinding into powder, and then roasting at 800°C in an air atmosphere for 8 hours with a heating rate of 10°C / min to obtain the magnetic core MgFe 2 o 4 . Sieve with a standard sieve to obtain a relatively uniform powder. The water used in the process is decarbonized deionized water.

[0044] (2) Preparation of magnetically intercalated diclofenac sodium magn...

Embodiment 3

[0048] (1) Magnetic core MgFe 2 o 4 Preparation of Nanopowder

[0049] Weigh 5.128g (0.02Mol) Mg (NO 3 ) 2 ·6H 2 O, 4.04g (0.01Mol) Fe(NO 3 ) 3 9H 2 O and 1.99g (0.01Mol) FeCl 2 4H 2 O was dissolved in 100ml water to make a mixed salt solution, and 6g (0.15Mol) NaOH and 7.42g (0.07Mol) NaOH were weighed 2 CO 3 Dissolve in 100ml of water to make a mixed alkaline solution; drop the alkaline solution into the mixed salt solution until the pH value is 11, crystallize in a water bath at 40°C for 10 hours, filter the reaction solution with suction, wash, and then wash with absolute ethanol Washing, vacuum drying, grinding into powder, and then roasting at 800°C in an air atmosphere for 8 hours with a heating rate of 10°C / min to obtain the magnetic core MgFe 2 o 4 . Sieve with a standard sieve to obtain a relatively uniform powder. The water used in the process is decarbonized deionized water.

[0050] (2) Preparation of magnetically intercalated diclofenac sodium magn...

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Abstract

The present invention is magnetic slow releasing diclofenac sodium in supermolecular intercalation structure and its preparation process, and belongs to the field of hydrotalcite material technology. The magnetic diclofenac sodium has the chemical expression of (M2+)1-x(N3+)x(OH)2(DIK-)a(Bn-)b.mH2O.kM'Fe2O4, and is prepared through the first coprecipitation process to prepare nanometer magnetic kernel, the subsequent mixing of the magnetic kernel with corresponding salt solution, and the final coprecipitation process to assemble diclofenac sodium into the hydrotalcite layers and to obtain the diclofenac sodium intercalated hydrotalcite with magnetic kernel. The magnetic slow releasing diclofenac sodium in supermolecular intercalation structure has high stability, raised bioavailability, capable of magnetic field location and targeting location and effective control on the medicine structure, composition, etc.

Description

technical field [0001] The invention belongs to the technical field of hydrotalcite materials, in particular to a sustained-release diclofenac sodium with a magnetic supramolecular intercalation structure and a preparation method thereof. Background technique [0002] Magnetic slow-release drugs are a kind of drugs that integrate magnetism and controlled release. When such drugs are used in the body, the magnetic field effect outside the body can guide the drug to move and concentrate in the body, and realize the controlled release of the drug. Therefore, such drugs are mainly used as carriers of anticancer drugs. Animal experiments and clinical observations have proved that magnetic drugs have a definite effect of inhibiting the growth of cancer cells, shrinking tumors of patients, and improving subjective symptoms. [0003] Existing magnetic sustained-release agent medicine has following two classes: 1) magnetic sustained-release tablet is to add ferromagnetic powder in su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/48A61K31/196A61K47/02A61P29/00
Inventor 张慧邹亢盘登科
Owner BEIJING UNIV OF CHEM TECH
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