Use of natural mulberry glucoside
A natural product, the technology of mulberry glycosides, which is applied in the directions of medical preparations containing active ingredients, drug combinations, respiratory diseases, etc., to achieve the effects of no toxic side effects, no addiction, and small dosage.
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Embodiment 1
[0015] Ammonia antitussive test in mice:
[0016] Mulberry glucoside (MUL) was administered ig at 0.04g / kg, 0.08g / kg, and 0.16g / kg, in a 4L bell jar, sprayed into concentrated ammonia water (25%) 8 times at constant pressure, and observed the cough latency and cough within 3min frequency. The blank control was 1% sodium carboxymethylcellulose, and the positive drug was pentoxyverine. The experimental results show (see table 1): mulberry glycoside (MUL) 0.08g / kg, 0.16g / kg can prolong the cough incubation period, the middle dose group (0.08g / kg) has significant difference compared with the blank group, the high dose group (0.16mg / kg) compared with the blank group has a very significant difference. The middle-dose group (0.08g / kg) and the high-dose group (0.16g / kg) can reduce the number of coughs in mice, and there are extremely significant differences compared with the blank group.
[0017] Table 1 The effect of mulberry glycosides on ammonia induced cough mice (x ± s)
[00...
Embodiment 2
[0022] Sulfur dioxide induced coughing method in mice
[0023] Mulberry glycoside (MUL) is administered with 0.01g / kg, 0.02g / kg, 0.04g / kg ig, after 1.5h after the administration, mice are put into a 250ml wide-mouth bottle filled with 5ml sulfur dioxide, and the cough latency is observed And the number of coughs within 3 minutes. The blank control was 1% sodium carboxymethylcellulose, and the positive drug was pentoxyverine suspension. The experimental results show (see Table 2): the high dose group (0.04g / kg) of molaritin (MUL), the middle dose group (0.02g / kg), and the low dose group (0.01g / kg) can all reduce the 3min The number of coughs within the low-dose group and the middle-dose group had significant differences compared with the blank group, and the high-dose group had a very significant difference compared with the blank group.
[0024] Table 2 The effect of mulberry glycosides on sulfur dioxide-induced cough mice (x ± s)
[0025]
[0026] * p** p<0.01 VS Contr...
Embodiment 3
[0028] guinea pig citric acid cough method
[0029] Mulberry glycoside (MUL) is administered with 0.02g / kg, 0.10g / kg, 0.20g / kg ig, puts into the experimental container after 1.5h after the administration, sprays into 40% citric acid solution with throat sprayer, Record the incubation period of the guinea pig cough, and the number of coughs within 5 minutes. The blank control was 1% sodium carboxymethylcellulose, and the positive drug was 0.01 g / kg of pentoxyverine suspension. The results show (see Table 3): the high-dose group (0.20g / kg) of mulberry glycoside (MUL), and the middle-dose group (0.10g / kg), both can prolong the cough latency of the factory guinea pig, and the middle-dose group is compared with the blank group There are significant differences, and there are extremely significant differences between the high-dose group and the blank group.
[0030] The effect of table 3 moriside on citric acid induced cough guinea pigs (n=8, x ± s)
[0031]
[0032] Guinea Pi...
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