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Method for preparing extract of korea thistle leaf

A technology of extracts and extracts, which is applied in the field of preparation of artichoke extracts, can solve problems such as decomposition of heat-sensitive active ingredients, complex production process routes, and influence on product purity, achieving bright color, avoiding oxidation and decomposition, and short production time Effect

Inactive Publication Date: 2007-07-18
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the route of the production process is too complicated, and various toxic and flammable organic solvents such as chloroform, ethyl acetate, n-butanol are used in the extraction process, which is easy to cause fire in industrial production
In addition, trace amounts of residual solvents will also affect the quality of the product
Patent CN1488381 also proposes a hot water extraction method of artichoke. Although the extraction process is short, its operation time is long, the material is kept at a high temperature for a long time, and the heat-sensitive active ingredients are seriously decomposed; Organic acids, which affect the purity of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Put 250g of powdered artichoke dry leaves into a 1L extraction kettle, and use CO 2 Replace and fill. Set extraction unit parameters, CO 2 Flow rate 20L / h, ethanol flow rate 0.3L / h; extractor pressure 35MPa, temperature 50°C; separator 1 pressure 8MPa, temperature 55°C, separator 2 pressure 5MPa, temperature 50°C. Continuous dynamic extraction for 2h, during which the extraction product was often collected from the outlet at the bottom of the separator. The obtained supercritical extract was evaporated at low temperature in vacuum, ethanol was removed therein, and dried to obtain 9.94 g of extract product, with an extraction rate of 3.97%.

Embodiment 2

[0020] 250g of powdery dried artichoke leaves are put into a 1L extraction kettle, and the supercritical extraction process is similar to that of Example 1. Set the parameters of the extraction device CO 2 The flow rate is 16L / h, and the ethanol flow rate is 0.3L / h; the pressure of the extractor is 30MPa, and the temperature is 50°C; the pressure of separator 1 is 7.6MPa, and the temperature is 55°C; the pressure of separator 2 is 4.6MPa, and the temperature is 50°C. Continuous dynamic extraction was performed for 3 hours, the product was collected, ethanol in the product was removed, and dried to obtain 9.60 g of extract product with an extraction rate of 3.84%.

Embodiment 3

[0022] 250g of powdery dried artichoke leaves are put into a 1L extraction kettle, and the supercritical extraction process is similar to that of Example 1. Set the parameters of the extraction device CO 2 Flow rate is 20L / h, ethanol flow rate is 0.3L / h; extractor pressure is 30MPa, temperature is 50°C; separator 1 pressure is 8.2MPa, temperature is 55°C, separator 2 pressure is 4.3MPa, temperature is 50°C. Continuous dynamic extraction was performed for 2 hours, the product was collected, ethanol in the product was removed, and dried to obtain 9.70 g of extract product with an extraction rate of 3.88%.

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Abstract

A process for preparing the extract of artichoke leaf includes such steps as providing dried leaves of artichoke, breaking, extracting in the mixture of supercritical CO2 and alcohol, separating twice, and low-temp vacuum evaporating to remove alcohol and obtain green extract.

Description

technical field [0001] The invention belongs to the extraction and processing method of natural products, and mainly relates to the preparation method of artichoke extract. Background technique [0002] Artichoke (Cynara scolymus L.), also known as artichoke, artichoke, French lily, is a large perennial herb of Compositae. Artichoke is a high-grade vegetable in the international market. But for a long time, people only eat its flower buds, and a large number of leaves are discarded. According to (Gebhardt R.Toxicol.Appl.Pharmacol.1997, 1144:279-286) reports, artichoke leaves contain a variety of polyphenols, such as caffeic acid, its functions are: antibacterial, analgesic, antioxidant, antiviral , hemostasis and gallbladder, etc.; another example is chlorogenic acid, which is an ester of caffeic acid and quinic acid, which has anti-tumor, anti-bacterial, anti-oxidation, anti-mutagenic functions; and flavonoids have anti-ulcer, anti-allergy, Antibacterial, anti-inflammato...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61P3/06A61P9/00A61P31/04A61P31/12A61P35/00A61P39/06A23L3/3472A61K127/00
Inventor 王龙虎谢志鹏刘雪松陈勇程翼宇
Owner ZHEJIANG UNIV
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