36-way rotary valve of simulated moving bed with high performance liquid preparative chromatography

Abstract

The invention discloses a 36-way rotation valve used in high-effect liquid spectrum analogue movable bed, wherein, the 36-way rotation valve is connected with one step motor mounted with a synchronous belt wheel. The valve mainly comprises a stable disc and a frame mounted on the stable disc, with a transmission axle between them, while one end of transmission axle is inserted into the central hole of stable disc, and another end is through out the frame to be mounted with another synchronous belt wheel. The circumferences of stable disc and frame are mounted with seal rings to be uniformly fixed; the movable disc, driving disc, disc spring, adjusting block and pushing bearing are mounted between the stable disc and the frame from down to upper. The inventive 36-way rotation valve can be used in the analogue movable bed which has four function areas while each area has four spectrum posts or less. The invention has compact structure, small volume and high reliability.

Description

technical field [0001] The invention relates to a rotary valve, in particular to a 36-way rotary valve used for high-performance liquid phase preparation of chromatographic simulated moving bed. Background technique [0002] In 1961, Broughton[Broughton D.B., US Pat[P].2 985 589(1961)] announced the method of using valve switching technology to change the positions of mobile phase injection point, sample injection point and separation collection point to realize countercurrent operation , thus giving birth to the simulated moving bed (Simulated moving bedchromatography, SMB) technology. Subsequently, this technology has been widely used in petroleum industry [Broughton D.B., ChemEng Prog, 1968, 64:60] and sugar industry [Hashimoto K., et al., J Chem Eng Jpn, 1983, 16:400]. In the early 1990s, Negawa, et al., et al [J. Chromatogr., 1992, 590: 113] applied SMB technology to separate the enantiomers of phenylethylamine. As the US FDA requires a single chirality for the listin...

AI Technical Summary

Problems solved by technology

This not only leads to complex connecting pipes and higher equipment costs, but also increases the risk of system failure with the increase in the number of solenoid valves

In addition, in the H-SMB, more than 30 solenoid valves and their associated pipes will lead to a significant increase in the extra-column volume of the system, especially in the laboratory-scale H-SMB system, this extra-column volume will lead to a significant increase in the separation efficiency of the system. decline

Rotary valves have been widely used in large-scale production of low-pressure liquid chromatography SMB systems, such as Chinese patent [Patent No.: 99240230233.6], [Patent No.: 00817918.2] and U.S. Patent [U.S.Pat.No.6,719,001] are given Out of their implementation, this type of rotary valve uses a very thick channel to realize the rotary switching of low-pressure flow, and uses a static disk to connect the sample and each chromatographic (or chromatographic) bed (column); developed by Knauer H-SMB (model CSEP-C912, annual output up to 1 ton) adopts a multifunctional rotary valve that connects the chromatographic column to the moving plate, so that the system is compact and the dead volume of the separation system is greatly reduced. Because the chromatographic column rotates with the moving plate, the length and weight of the chromatographic column are limited to a certain extent, which limits the application of this multifunctional rotary valve in H-SMBs exceeding the limit column length and weight.

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