Rabdosia serra (Maxim.) hara extract, preparing process and application thereof

A technology of Xihuangcao and extract, which is applied in the field of traditional Chinese medicine, can solve problems such as difficult retention, backward preparation technology, and inconvenient administration.

Inactive Publication Date: 2007-08-08
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these varieties generally have disadvantages such as backward preparation technology, large dosage, inconvenient taking and unsatisfactory effect.
At present, the development level of my country's pharmaceutical industry is relatively backward, and new technologies and processes are difficult to popularize due to reasons such as concepts and objective conditions. The preparation of medicines for treating hepatitis B with Chinese medicinal materials mainly uses water decoction and water decoction. The active ingredients

Method used

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  • Rabdosia serra (Maxim.) hara extract, preparing process and application thereof

Examples

Experimental program
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Effect test

example 1

[0060] Take 2000g of fresh and dried Xihuangcao, cut into 1-2cm pieces.

[0061] Take a small section of Xihuangcao, add 12 times of water, soak for 12 hours, heat and extract at 100°C for 1.5 hours, filter while hot, add 10 times of water to the dregs, heat and extract for 1 hour, and filter while hot. Combine the two ethanol extracts; concentrate the water extract to contain 0.90g of the original medicinal material per milliliter, ultracentrifuge at 5000rpm at 5-20°C, take the supernatant and add it to the treated AB-8 macroporous adsorption resin (produced by Tianjin Nankai University Chemical Factory), with a flow rate of 2BV / h (column volume per hour) on the macroporous adsorption resin column, after the adsorption is saturated, first use 6BV water to elute with a flow rate of 1.5BV / h, and then sequentially Elute with 5BV of 60% ethanol and 10BV of 80% ethanol at a flow rate of 1BV / h, collect the eluate with a concentration of 80% ethanol, concentrate, and spray dry.

[...

example 2

[0064] Take 1000g of fresh and dried Xihuangcao, cut into 1-2cm pieces.

[0065] Take a small section of Xihuangcao, add 15 times of water, soak for 12 hours, heat and extract at 100°C for 1.0 hour, filter while hot, add 10 times of water to the dregs, heat and extract for 0.5 hour, and filter while hot. Combine the two ethanol extracts; concentrate the water extract to contain 0.74g of the original medicinal material per milliliter, ultracentrifuge at 8000rpm at 5-20°C, take the supernatant and add it to the treated AB-8 macroporous adsorption resin (produced by Tianjin Nankai University Chemical Factory), with a flow rate of 3BV / h (column volume per hour) on the macroporous adsorption resin column, after the adsorption is saturated, first use 6BV water to elute with a flow rate of 0.8BV / h, and then sequentially Elute with 3BV 60% ethanol, 6BV 80% ethanol at a flow rate of 1BV / h, collect the 80% ethanol eluate, concentrate, and spray dry; the resulting extract contains 3.24% ...

example 3

[0067] Take 2000g of fresh and dried Xihuangcao, cut into 1-2cm pieces.

[0068] Take a small section of Xihuangcao, add 12 times of water, soak for 12 hours, heat and extract at 100°C for 1.5 hours, filter while hot, add 10 times of water to the dregs, heat and extract for 1 hour, and filter while hot. Combine the two ethanol extracts; concentrate the water extract to contain 0.90g of the original medicinal material per milliliter, ultracentrifuge at 500rpm at 5-20°C, take the supernatant and add it to the treated AB-8 macroporous adsorption resin (produced by Tianjin Nankai University Chemical Factory), with a flow rate of 2BV / h (column volume per hour) on the macroporous adsorption resin column, after the adsorption is saturated, first use 6BV water to elute with a flow rate of 1.5BV / h, and then sequentially Elute with 5BV 60% ethanol, 8BV 80% ethanol at a flow rate of 1BV / h, collect the 80% ethanol eluate, concentrate, and spray dry; the resulting extract contains 3.81% 2α...

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Abstract

The invention relates to an erysimoside extractive which comprises 1.58-2.63% oleanolic acid, 4.87-6.17% prunol, 3.16-4.47% 2-alpha-hydroxy prunol, 3.24-4.28% 2-alpha, 19-alpha-pomolic acid. And the preparation comprises that immerging the erysimoside into water, heating and extracting at normal pressure, passing the extractive via the porous adsorption resin, washing with alcohol, collecting the solution whose alcohol density is 60-95%, depressurizing and concentrating, atomizing and drying. The invention uses the porous adsorption resin to extract the effective components of erysimoside, to hold the thermal-sensitive components as oleanolic acid, prunol, 2-alpha-hydroxy prunol, and 2-alpha, 19-alpha-pomolic acid.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to extracts of traditional Chinese medicines, in particular to extracts of Herba xihuangcao. Background technique [0002] Xihuangcao is the dry whole plant of Isodon lophanthoides (Benthan) H.Hara, a plant of the genus Lamiaceae, and its variant Isodon lophanthoides var. gerardianus (Benthan) H.Hara. It has the effects of clearing heat and dampness, reducing jaundice, cooling blood and dissipating blood stasis. It is a commonly used herbal medicine for treating hepatitis B in southern my country. It is widely used clinically and has definite curative effects. At present, there are many liver-nourishing and liver-protecting medicines with it as the main raw material. Traditional Chinese medicine preparations and health products, such as Xiaoyan Lidan Tablets, Xihuangcao Oral Liquid, Shiwei Xihuangcao, etc. But these kind ubiquitous preparation crafts are backward, and dos...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P1/16A61P31/12C07J63/00
Inventor 祝晨蔯林朝展
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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