Water soluble chitosan derivative and preparing method thereof
A technology for water-soluble chitosan and derivatives, applied in the field of derivatives of natural polymer compounds and their preparation, can solve the problem of high cost and achieve the effects of low cost and easy industrialization
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Embodiment 1
[0029] Add 5g of chitosan into 250g of 1wt% acetic acid aqueous solution, stir until completely dissolved, then add 1g of maleic anhydride, react at 30°C for 10 hours, after the reaction is completed, dialyze and vacuum dry to obtain 7g of maleamic acid chitosan sugar. Curve a in Fig. 1 is the infrared spectrum of chitosan, and curve b in Fig. 1 is the infrared spectrum of maleamic acid chitosan. As can be seen from comparative analysis, in the infrared spectrum of maleamic acid chitosan, the C=0 vibration of the amide formed by the maleamic acid chitosan amino group on the chitosan is at 1712cm -1 There is a strong absorption peak, at the same time, located at 1630cm -1 Nearby absorption peaks corresponding to double bonds. Figure 2 shows the maleamic acid chitosan 1 H NMR spectrum. It mainly includes two groups of peaks: one group is at 5.5-6.0ppm, which is attributed to the absorption of double bond hydrogen in maleyl group; the other group is a broad peak at 2.0-5.0ppm...
Embodiment 2
[0031] Add 5g of chitosan into 250g of 2wt% acetic acid solution, stir until completely dissolved, then add 1g of succinic acid, react at 30°C for 15 hours, dialyze, and vacuum dry to obtain 7.5g of succinamic acid chitosan. Fig. 4 is the infrared spectrogram of succinamic acid chitosan. Compared with chitosan, the maximum change of infrared spectrum after reaction is at 1700-1750cm -1 A strong absorption peak appears in the range, which is the C=0 vibration of the amide formed by the acylation reaction of the amino group on chitosan, and at the same time at 2800-3000cm -1 Characterize -CH or -CH in the range 2 the absorption peak. Figure 5, 6 is the succinamic acid chitosan 1 H NMR spectrum and 13 C NMR spectrum. At room temperature, 6.2g maleamic acid chitosan can be dissolved in 100mL water. Chitosan as a raw material is insoluble in water.
Embodiment 3
[0033] Add 5 g of chitosan into 250 g of 1 wt % acetic acid solution, stir until completely dissolved, then add 2 g of adipic acid, react at 30° C. for 10 hours, dialyze, and vacuum dry to obtain 8 g of adipamic acid chitosan. At room temperature, 6.1 g of adipamic acid chitosan can be dissolved in 100 mL of water. Chitosan as a raw material is insoluble in water.
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