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Method for refining Radix astragali polysaccharide

A technology of astragalus polysaccharide and microfiltration membrane, which is applied in the field of pharmacognosy, can solve the problems of low extraction rate and purity of astragalus polysaccharide, long heating time, complicated steps, etc., to avoid thermal decomposition, simple method, increase extraction rate and The effect of product purity

Inactive Publication Date: 2007-09-05
SHANGHAI INST OF PHARMA IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the current problem of extracting and separating astragalus polysaccharides from astragalus, long heating time, high energy consumption, and complicated steps, resulting in low extraction rate and purity of astragalus polysaccharides and low efficiency, the present invention is proposed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 1 kg of Radix Astragali, pulverize it, and extract it by microwave (70°C, 4 times, 30 minutes / time) to obtain a water extract. Filter, and then pass the filtrate through a 0.2 μm microfiltration membrane, and add 4 times the amount of water to dilute during the process of passing through the membrane (continuously add water according to the amount of permeation). The filtrate was collected and concentrated through an ultrafiltration membrane with a molecular weight cut-off of 1,000 Daltons. The retentate was collected, precipitated with alcohol, and dried to obtain 81.50 grams of astragalus polysaccharides with a purity of 86.29% (measured by the phenol-sulfuric acid method, the same below).

Embodiment 2

[0025] Take 1 kg of Radix Astragali, pulverize it, and extract it by microwave (70°C, 4 times, 30 minutes / time) to obtain a water extract. Filter, and then pass the filtrate through a 1.4 μm microfiltration membrane, and add 2 times the amount of water to dilute during the process of passing through the membrane (continuously add water according to the amount of permeation). The filtrate was collected and concentrated through an ultrafiltration membrane with a molecular weight cut-off of 10,000 Daltons. The retentate was collected, precipitated with alcohol, and dried to obtain 71.36 grams of astragalus polysaccharide with a purity of 89.73%.

Embodiment 3

[0027] Take 1 kg of Radix Astragali, pulverize it, and extract it by microwave (70°C, 4 times, 30 minutes / time) to obtain a water extract. Filter, and then pass the filtrate through a 0.14 μm microfiltration membrane, and add 5 times the amount of water to dilute during the process of passing through the membrane (continuously add water according to the amount of permeation). The filtrate was collected and concentrated through an ultrafiltration membrane with a molecular weight cut-off of 5,000 Daltons. The retentate was collected, precipitated with alcohol, and dried to obtain 77.93 grams of astragalus polysaccharide with a purity of 81.86%.

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Abstract

A process for refining astragalus polyose features the combination of microwave extracting, microfilter, ultrafiltration and alcohol deposition, resulting in high output rate and purity, and short period.

Description

technical field [0001] The invention relates to the field of pharmacognosy, in particular to a method for refining astragalus polysaccharides by combined application of microwave extraction, microfiltration, ultrafiltration and alcohol precipitation techniques. Background technique [0002] Radix Astragalus (Radix Astragalus) is the dried root of Astragalus membranaceus (Fisch) Bge or Astragalus membranaceus (Fisch) Bge.Var.mongholicus (Bge) Hsiao) of the leguminous plant. Sweet, slightly warm in nature, invigorating qi and solidifying the surface, diuresis and treating sores. Modern pharmacological studies have shown that astragalus polysaccharide is one of the main components of astragalus, which has a wide range of pharmacological effects such as improving immunity, anti-tumor, anti-radiation damage, antibacterial and anti-virus, regulating blood sugar, and anti-aging. [0003] The method of extracting and isolating astragalus polysaccharides from astragalus is mainly wa...

Claims

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Application Information

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IPC IPC(8): C08B37/00
Inventor 杨义芳许海燕黄春跃
Owner SHANGHAI INST OF PHARMA IND
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