Garlic seed aqueous extracts for killing schistosoma japonicum cercariae

A technology of schistosome cercariae and garlic seeds, which is applied to the field of killing schistosome cercariae by garlic seed extract, can solve the problems of skin irritation, thick protective agent, easy falling off, etc., and achieves rich material sources, low price and good effect Effect

Inactive Publication Date: 2007-09-19
YANGTZE UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the drugs used to kill cercariae and prevent cercariae infection are mainly ointments and emulsions made from chemicals such as methylenedibutyl phthalate and niclosamide. Although various protective agents made from these drugs have It has a strong effect of killing cercariae, but the cost is high, and this kind of ointment, paste, and oil-based protective agent are thicker, thicker on the skin, and have strong irritation to the skin, sometimes due to labor Friction is easy to fall off, it is difficult to popularize and use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Test for killing Schistosoma japonicum cercariae.

[0014] Dilute 100% of the garlic seed stock solution with distilled water into 50%, 25%, 12.5%, 6.25%, 3.13%, 1.57%, and 0.79% of the garlic seed extract, and then use concentrations of 100%, 50%, and 25% respectively. %, 12.5%, 6.25%, 3.13%, 1.57%, and 0.79% garlic seed infusion 100 microliters, each placed on a glass slide, 40 live Schistosoma japonicum cercariae were added to each slide, and the records were observed under an anatomical microscope The time to kill the cercariae of Schistosoma japonicum was determined by touching the cercariae of Schistosoma japonicum with anatomical needles.

[0015] Garlic seed concentration (%)

[0016] Garlic seed liquid kills the cercariae of Schistosoma japonicum test results: the garlic seed stock solution can quickly kill the cercariae of Schistosoma japonicum within 2 seconds, and the average time for garlic seed infusion with a concentration of 50% to 0...

Embodiment 2

[0017] Embodiment 2: Animal infection test.

[0018] For the first time, 40 small white mice were used for the test, and the abdomen of each small white mouse was shaved. The range of shaved hair was 2 cm × 3 cm, and 0.1 ml of 10% chloral hydrate was injected subcutaneously for anesthesia. %, 50%, 25%, 12.5%, 6.25%, 3.13%, 1.57%, 0.79% garlic seed infusion 100 microliters on each glass slide, put 40 Schistosoma japonicum cercariae on each slide, 30 Minutes later, it was pasted on the abdomen of each anesthetized mouse, and the infection time was 20 minutes. Five mice were infected in each concentration group. After 40 days, the animals were dissected, and the cercariae of Schistosoma japonicum were collected by perfusion and shredding. The method is as follows: firstly, the superior vena cava of the mice is perfused and washed, and the number of adults of Schistosoma japonicum in the liver and intestinal venous plexus is counted under a dissecting microscope. Smash and chec...

Embodiment 3

[0023] Embodiment 3: smear 50% garlic seed infusion on the feet, hands and arms of the human body, work in paddy fields or wash rice and vegetables, which can prevent the invasion of Schistosoma japonicum cercariae and prevent Schistosoma japonicum infection.

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PUM

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Abstract

A garlic seed immersion fluid for killing japaneses schistosomulum, is composed of garlic seed immersion fluid and water. The garlic seed is peeled off the skin, and then squeezed by clear water dechlorinated after airing to become the raw liquor of the garlic seed fluid, at last the garlic seed immersion fluids of various concentrations above 0.79% are prepared by distilled water for killing japaneses schistosomulum. A great variety of emulsion, slurry, aqua and oil are prepared by the garlic seed immersion fluid as protective agents for skin protection against the penetration of the japaneses schistosomulum, namely avoiding the infection of the japaneses schistosomulum. The garlic seed immersion fluid is natural product, the features of which comprise small skin irritation, low price, economy, practicality.

Description

Technical field: [0001] The invention relates to articles for killing schistosomiasis, in particular to killing cercariae of schistosome japonicum with garlic seed extract. Background technique: [0002] Schistosomiasis is a disease that seriously endangers the health and life safety of the people. The areas where schistosomiasis has not been controlled in China are mainly concentrated in 110 counties, cities, and districts in Hunan, Hubei, Jiangxi, Anhui, Jiangsu, Sichuan, and Yunnan in the Yangtze River Basin, and the population living in the affected areas is about 60 million. Due to the needs of production and life, people often have to contact infected water, wet grass, and wet soil with schistosomiasis cercariae to cause infection. In 2004, the number of schistosomiasis patients in the country reached 843,000. In recent years, the number of schistosomiasis infections has risen sharply, and the state invests a lot of manpower, material and financial resources every yea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61K9/06A61K9/08A61K9/10A61K9/107A61P33/12A61K125/00
CPCY02A50/30
Inventor 丁克清邓德明任伯绪边藏丽张爱华丁义玲
Owner YANGTZE UNIVERSITY
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