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The treatment of inflammatory disorders and pain

A technology for inflammatory cytokines and diseases, applied in the field of treatment of inflammatory diseases and pain, can solve problems such as side effects, compliance, and inconvenient route of administration

Inactive Publication Date: 2007-09-26
SOSEI R&D LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These treatments often have inconvenient routes of administration and severe side effects, leading to compliance issues

Method used

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  • The treatment of inflammatory disorders and pain
  • The treatment of inflammatory disorders and pain

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Embodiment Construction

[0022] The compound of general formula (I) includes wherein R 1 Those that are aryl or heteroaryl and where R 1 Is CHR 4 -OR 5 Of those. The specific compounds used in the present invention include salbutamol, amiforin, amiterol, arotinol, bambuterol, parmesan, isothalin mesylate, bucrolol, butidrine, Butoxamine, carbuterol, cimaterol, clenbuterol, cloprenaline, colterol, ditenol, diacetyl isoproterenol, dichloroisoproterenol, di Hydroxyephedrine, dimethicone, dipinephrine, divabuterol, epinephrine, ephedrine, etivaterol, fenoterol, flubuterol, salibuterol, isobubuterol, Ethylisoproterenol, isoproterenol, isoproterenol, isoproterenol, mabuterol, meludrine, menetyl, metalol, metaproterenol, metacaterol , Isoproterenol, nifedipine, hydroxynorephedrine, oloforin, phenylephrine, procaterol, propranolol, pseudoephedrine, quiprerenaline, linmeterol, salbutamol , Sotalol, soterolol, sulfonylbuterol, suloproteol, sympathol, terbutaline and toloterol; apronol, atenolol, phenfurolol, benfur...

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Abstract

Compounds that may be used for the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro-inflammatory cytokines are of formula (I): wherein R1 is CHR4-OR5 or CHR4-SR5, or aryl or heteroaryl optionally substituted with one or more groups R6; R2 is alkyl or is part of a ring with R3; R3 is H, alkyl or CH2 (when forming part of a ring with R2); R4 is H or alkyl or is part of a ring with R5; R5 is aryl or heteroaryl optionally substituted with R7; each R6 is independently alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, SO2NH2, Salkyl, CH2SO2alkyl or OCONalkyl2; R7 is R8 or (CH2)nOR8, R9, CF3, OH, OR9, OCOR9, COR9, COOR9, CONH2, CH2CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHCONHR7, NHCON(R9)2, NHCOR9, NHCOaryl, NHSO2Me, CONH2, SMe, SOMe or SO2NH2; R8 is (CH2)nOR9, (CH)nOR9, (CH2)nCOOR9 or (CH2)nCOaryl; R9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof, including clenbuterol and atenolol.

Description

Invention field [0001] The present invention relates to the treatment of inflammatory diseases and pain. Background of the invention [0002] Immune-driven inflammatory activity is an important cause of many chronic inflammatory diseases, in which long-lasting inflammation can lead to tissue destruction, and cause extensive damage to the affected organs and ultimately failure. The cause of these diseases is unknown, so they are often referred to as autoimmune, because they seem to be caused by the individual's immune system turned on by itself. This includes those conditions involving multiple organs, such as systemic lupus erythematosus (SLE) and scleroderma. Other types of autoimmune diseases can include specific tissues or organs such as musculoskeletal tissue (rheumatoid arthritis, ankylosing spondylitis), gastrointestinal tract (Crown disease and ulcerative colitis), central nervous system ( Alzheimer's disease, multiple sclerosis, motor neuron disease, Parkinson's disease a...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K31/138A61K31/37A61K31/4458A61K31/4704A61P1/00A61P1/02A61P11/06A61P11/08A61P13/12A61P17/00A61P19/02A61P19/10A61P25/02A61P29/02
Inventor A·D·巴克斯特J·布鲁
Owner SOSEI R&D LTD
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