Detecting biologic sensor associating evanescent field and flexible flat plate wave

A biosensor and evanescent field technology, applied in the field of biosensors, can solve the problems of large deviation of test results, inability to know whether the absorption layer contains too much moisture or other non-specific substances, inability to distinguish non-specific adsorption, etc.

Inactive Publication Date: 2008-01-23
CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

A major limitation of this detection method is that it cannot distinguish non-specific adsorption. The change of SPR incident light resonance angle is a function of the thickness and refractive index of the absorbing layer. It is impossible to know whether the absorbing layer contains too much water or other non-specific substances. Often cause large deviations in test results

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  • Detecting biologic sensor associating evanescent field and flexible flat plate wave

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Embodiment Construction

[0011] The structure of the biosensor of the present invention will be further described in detail with reference to the embodiments given in the accompanying drawings.

[0012] Referring to Fig. 1, a biosensor for joint detection of evanescent field and flexible plate wave is composed of an optical sensing component and an acoustic wave sensing component. The optical fiber 1; the acoustic wave sensing part is made of a silicon film 4 and a layer of aluminum formation 6 sputtered by a magnetron sputtering process on the bottom surface of the silicon film 4, and then sputtered on the aluminum formation 6 An aluminum nitride piezoelectric film 7 formed of a layer of aluminum nitride is formed by laying interdigitated electrodes 8 on the outer surface of the aluminum nitride piezoelectric film 7; the optical fiber support 5 is fixed on the silicon film 4, and the A microfluidic groove 3 capable of carrying detected objects is formed between the support 5 and the hollow surface in...

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Abstract

The invention relates to a biologic detecting sensor combining evanescent field with flexible plate wave that is applicable for detecting the biologic affinity reaction feature in such fields as clinic inspection, medicine screening, environment and food inspection, etc., which comprises an optic sensing component and a sound wave sensor, between which a sample pond for bearing the object to be detected is arranged. By the biologic sensor, a plurality of parameters of the object can be measured in the same test condition, and the accuracy of the physical characterization of the biologic reacting object can be greatly improved.

Description

technical field [0001] The invention relates to a biosensor suitable for detection of bioaffinity reaction characteristics in the fields of clinical testing, drug screening, environment, food testing, etc., especially a biosensor capable of synchronously detecting the quality of bioreaction conjugates and substrate refractive index, dielectric constant and other physical quantities Changing biosensors. Background technique [0002] The detection of biological affinity is not limited to the chemical process of biological reactions, but to detect the process and results of biological reactions based on various information of biological reactions, such as light, heat, field effects, and mass changes. ratio, the detection time can be greatly shortened. In bioaffinity detection, transduction methods such as optics, electrochemistry, and acoustic waves have the advantages of high sensitivity and real-time continuous detection, and have become the mainstream of current biosensing ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48G01N21/55G01N29/00G01N21/552
Inventor 吴一辉李锋郝鹏庄须叶刘永顺王淑荣
Owner CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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