Application of compound 1-( 4-chloroaniline )-4-( 4-picoline )-2, 3-naphthyridine

A picoline-based and chloroaniline-based technology, applied in the field of compound 1--4--2, can solve the problem of tumor tissue killing

Active Publication Date: 2008-02-06
BIOLOGY INST OF SHANDONG ACAD OF SCI
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, unfortunately, in fact, once the tumor has appeared, angiogenesis inhibitors can inhibit the formation of new blood vessels, but they cannot kill the already formed tumor blood vessels and tumor tissues that have grown up, so it is necessary to apply angiogenesis inhibitors in advance , it is more realistic to prevent the occurrence of tumor diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of compound 1-( 4-chloroaniline )-4-( 4-picoline )-2, 3-naphthyridine
  • Application of compound 1-( 4-chloroaniline )-4-( 4-picoline )-2, 3-naphthyridine
  • Application of compound 1-( 4-chloroaniline )-4-( 4-picoline )-2, 3-naphthyridine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] Technical scheme of the present invention is as follows:

[0011] Use of the compound 1-(4-chloroanilino)-4-(4-methylpyridyl)-2,3-naphthyridine of the following formula in the preparation of drugs for preventing the occurrence of tumor diseases.

[0012]

[0013] The term "prevention" in the present invention means that the occurrence and formation of tumors is at least delayed or avoided, and tumor patients treated with drugs containing the above compounds have a higher survival rate than those without prevention.

[0014] The term "neoplastic disease" in the present invention means a neoplastic proliferative disorder, such as a solid tumor disease. The term "solid tumor disease" as used herein refers especially to breast cancer, ovarian cancer, cervical cancer, colon cancer and usually gastrointestinal cancer, lung cancer, kidney cancer, bladder cancer, prostate cancer, skin cancer, head and neck cancer or brain tumors.

[0015] In the present invention, the term ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the use of compound 1-(4-chlorobenzene amidocyanogen)-4-(4-methylpyridine)-2, 3-phthalazine in preparing medicine used for preventing tumor diseases, wherein the medicine contains 1-(4-chlorobenzene amidocyanogen)-4-(4-methylpyridine)-2, 3-phthalazine and is used through administration method via or outside intestines and stomach. The compound can at least prolong or avoid occurrence or formation of tumor; moreover, tumor patient adopting medicine containing the compound for prevention obtains higher survival rate as compared with the patient who does not adopt the prevention method.

Description

technical field [0001] The invention relates to the application of a compound 1-(4-chloroanilino)-4-(4-methylpyridyl)-2,3-naphthyridine. technical background [0002] Angiogenesis involves the de novo formation of blood vessels from endothelial cell precursors or hemangioblasts. The first vascular structures in the embryo are formed by angiogenesis. Angiogenesis involves the development of capillaries from existing blood vessels and is the primary mechanism by which organs such as the brain and kidney form blood vessels. Although restricted to embryonic development, angiogenesis can occur in adults, for example during pregnancy, the female cycle, or wound healing. [0003] The major regulator of angiogenesis and angiogenesis in embryonic development and in certain angiogenesis-dependent diseases is vascular endothelial growth factor (VEGF). VEGF represents a family of mitogen isoforms that arise from alternative RNA splicing and exist as homodimers. VEGF can bind tyrosin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/501A61P35/00
Inventor 刘可春韩利文王加宁陈贯虹姜平王思锋于承建
Owner BIOLOGY INST OF SHANDONG ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap