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Method for making micro-magnetic field integrated polyalcohol microflow control device

A technology of a microfluidic device and a manufacturing method, which is applied in the field of micro-total analysis systems, can solve problems such as high cost, low integration, and complicated processing, and achieve simple processing and manufacturing processes, in-situ integration, and direction controllable effect

Inactive Publication Date: 2011-07-27
WUHAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in the microfluidic system, the manipulation of magnetic particles is generally achieved by using an external magnetic field or micro-machining technology to obtain a micro-electromagnetic field. The former is to place a permanent magnet or an electromagnet directly outside the chip. This passive magnetic particle The separator is easy to process, but lacks in-situ performance, low integration and relatively large device. The latter integrates the electromagnet on the chip by micromachining. The chip produced by this method has high integration, but the processing process is complicated. ,high cost

Method used

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  • Method for making micro-magnetic field integrated polyalcohol microflow control device
  • Method for making micro-magnetic field integrated polyalcohol microflow control device
  • Method for making micro-magnetic field integrated polyalcohol microflow control device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Prepare the silicon positive mold template for the polydimethylsiloxane microfluidic chip by soft etching;

[0027] (2) winding 40 turns of enamelled copper wire on an iron core with a diameter of 1mm to make a microcoil (4), wherein the diameter of the enamelled copper wire is 0.1mm;

[0028] (3) Two 40-turn microcoils (4) are fixed on both sides of the microchannel on the silicon positive mold template, the angle between the coils is 120°, and the plane formed by the two coils and the plane of the template are clamped. The angle is 60°;

[0029] (4) Mix the polydimethylsiloxane monomer and the curing agent in a ratio of 10:1, stir thoroughly, remove air bubbles and pour it on the silicon positive mold template for fixing the microcoil, and cure at 80°C for 3 hours, Then the cured polydimethylsiloxane is peeled off from the silicon positive mold template to make a chip substrate with microcoils (4) and microchannels (3);

[0030] (5) Punch holes on the chip subst...

Embodiment 2

[0032] (1) A positive glass mold template for the polydimethylsiloxane microfluidic chip is prepared by soft etching;

[0033] (2) Winding 60 turns of enamelled copper wire on an iron core with a diameter of 1.2mm to make a microcoil; wherein the diameter of the enamelled copper wire is 0.1mm;

[0034] (3) Two 60-turn microcoils are fixed on both sides of the microchannel of the glass male template, the angle between the coils is 120°, the plane formed by the two coils and the plane of the glass male template the angle is 90°;

[0035] (4) Mix the polydimethylsiloxane monomer and the curing agent in a ratio of 10:1, stir well, remove air bubbles, pour it on the glass positive mold template for fixing the microcoil, and cure it at 80°C for 3 hours, The cured polydimethylsiloxane is then peeled off from the positive glass template to make a chip substrate with microcoils and microchannels;

[0036] (5) Punch holes on the chip substrate with a puncher, and then treat the surfac...

Embodiment 3

[0038] (1) Prepare the silicon positive mold template for the polydimethylsiloxane microfluidic chip by soft etching;

[0039] (2) Winding 60 turns of enamelled copper wire on an iron core with a diameter of 1.5mm to make a microcoil, wherein the diameter of the enamelled copper wire is 0.1mm;

[0040] (3) Two 60-turn microcoils are fixed on both sides of the microchannel of the silicon positive mold template, the angle between the coils is 60 °, the plane formed by the two coils and the plane of the silicon positive mold template The included angle is 90°;

[0041] (4) Mix the polydimethylsiloxane monomer and the curing agent in a ratio of 10:1, stir well, remove air bubbles and pour it on the chip silicon positive mold template for fixing the microcoil, and cure at 80°C for 3 hours , and then peel off the cured polydimethylsiloxane from the silicon positive mold template to make a chip substrate with microcoils and microchannels;

[0042] (5) Punch holes on the chip substr...

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Abstract

The invention disclsoses a method for maufacturing a micromagnetic field integrated microflow control device, comprising: 1) preparing male die template for polymer microflow control chip by soft etch method; 2) winding 10-120 turns of wire on the soft magnetic material to make micro coils, wherein the surface of the wire is insulated; 3) securing a plurality of micro coils on the micro channels of the male die template, such that the micro coils are perpendicular to the plane of the male die template; fixing the plurality of micro coils on the two sides of the micro channels of the male die template, with an included angle between the micro coils being 0-180 DEG, and an included angle between the plane of the micro coils and that of the male die template being 0-90 DEG; 4) pouring the liquid prepolymer used for making the polymer microflow control chip on the male die template; solidifying, demoulding and forming to make the chip substrate with micro coils and micro channels, usinga hole puncher to make holes in order to make linkage with a cover plate, thus forming the micromagnetic field integrated microflow control device. The method has simple manufacturing process and low cost, the obtained magnetic field has controllable switch, size and direction, as well as the characteristic of in situ and high integration.

Description

technical field [0001] The invention relates to a manufacturing method of a polymer microfluidic device integrated with a micromagnetic field, and belongs to the field of micro total analysis systems. Background technique [0002] Microfluidic chip technology was developed in the field of analytical chemistry in the 1990s. It is characterized by a micro-pipeline network and takes life science as its main research object. The functions of the entire laboratory include sample pretreatment, reaction, separation, The integration of detection and so on on the microchip greatly improves the analysis speed, has extremely wide applicability and application prospects, and is the focus of current research on micro-total analysis systems. [0003] At the same time, magnetic particles have become another research hotspot due to their good maneuverability. At present, in the microfluidic system, the manipulation of magnetic particles is generally achieved by using an external magnetic f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N35/00G01N31/00
Inventor 张志凌刘妍君庞代文国世上黄卫华陈勇
Owner WUHAN UNIV
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