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Good stability chloromycetin eyedrop and preparation method thereof

A technology of chloramphenicol and eye drops, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems that the shelf life can only reach one year and it is unfavorable for patients to use.

Active Publication Date: 2010-09-01
SINOPHARM GRP SANYI PHARMA WUHU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent CN1872038A has introduced dropping pill type chloramphenicol eye drops and preparation method thereof, and it isolates chloramphenicol and aqueous solution by preparing the main drug chloramphenicol into the form of dropping pills, thereby reaching the purpose of prolonging the period of validity of the medicine, but Because the solubility of chloramphenicol in water is slightly soluble, the above-mentioned drugs must be shaken for a long time to dissolve chloramphenicol when used, which is not conducive to the use of patients
[0004] Chinese patent CN1163266C discloses a kind of eye drops for the treatment of conjunctivitis and keratitis eye disease, it improves its anti-staphylococcus aureus, escherichia coli sterilization rate, but the shelf life of the above products can only reach one year

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, 0.4 grams of licorice flavonoids with a purity of 10%, add water to 1000 milliliters, and the pH value of the solution is 6.4.

Embodiment 2

[0035] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.3 grams of licorice flavonoids with a purity of 25%, and add water to 1000 milliliters.

Embodiment 3

[0037] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.1 grams of licorice flavonoids with a purity of 40%, and add water to 1000 milliliters.

[0038] Embodiment 1 result is as shown in table 1:

[0039] Table 1:

[0040]

[0041] Embodiment 2 result is as shown in table 2:

[0042] Table 2:

[0043]

[0044] Embodiment 3 results are as shown in table 3:

[0045] table 3:

[0046]

[0047] Examples 1-3 show that when the weight concentration of licorice flavonoids with a purity of 35% in the solution is 0.01-0.04%, the present invention can be realized.

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PUM

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Abstract

The present invention relates to a kind of chloramphenical eye drops. Its raw material composition is formed from chloramphenicol, buffer solution and water, and is characterized by that in its solution a licochalcone whose weight concentration is 0.01-0.04% and purity is 2-40% can be contained, so that the stability of said eye drops can be greatly raised.

Description

technical field [0001] The invention belongs to chloramphenicol eye drops and a preparation method thereof, in particular to chloramphenicol eye drops containing licorice flavonoids and a preparation method thereof. Background technique [0002] Chloramphenicol eye drops is a commonly used drug for the eyes. It is a drug recorded in the second part of the "Chinese Pharmacopoeia" in 2005. It was once used as an OTC Class A drug in the market. Its main ingredients are chloramphenicol, Buffers, bacteriostats, water, and sodium hyaluronate and glycerin are also added to chloramphenicol eye drops to enhance viscosity and improve retention time in the eyes. The usual shelf life of medicines is 2 years, but the shelf life of chloramphenicol eye drops can only reach 8-12 months, this is because chloramphenicol in chloramphenicol eye drops is easily decomposed into chloramphenicol Nitrobenzaldehyde, chloramphenicol diol and p-nitrobenzaldehyde are highly irritating to the eyes and a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/165A61K47/22A61P27/02
Inventor 张咏梅
Owner SINOPHARM GRP SANYI PHARMA WUHU CO LTD