Ebstine solid oral preparation and its preparing method
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An oral preparation, the technology of ebastine, applied in the pharmaceutical field, can solve the problems of people who are not easy to obtain drinking water or tourists, inconvenience and the like
Active Publication Date: 2008-04-16
HUBEI LIYI PHARM TECH CO LTD
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Abstract
Description
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Problems solved by technology
[0005] At present, only ordinary tablets of ebastine are on the market in China, which brings inconvenience to those who have difficulty swallowing, such as the elderly and children, as well as those who do not have easy access to drinking water at work or tourists
Method used
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[0085] An ebastine orally disintegrating tablet is made of the following raw materials in parts by weight:
[0086] Example 1
Example 2
Example 3
Example 4
Example 5
raw material
parts by weight
parts by weight
parts by weight
parts by weight
parts by weight
Ebastine
95% ethanol solution
80% ethanol solution
tartaric acid
citric acid
Mannitol
Lactose
pregelatinized starch
microcrystalline cellulose
Cross-linked CMC
Crospovidone
aspartame
stevia
Menthol
Talc powder
Micropowder silica gel
10
40
0
0
0
60
0
40
0
8
0
1
0
0
2
0
10
40
0
5
0
60
0
40
0
8
0
1
0
0
2
0
10
15
0
0
3
0
60
0
30
0
10
0
2
0.5
0
10
10
0
15
0
8 (4 servi...
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PUM
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Abstract
An ebastine solid oral preparation and preparation method are disclosed in the present invention. Made of ebastine, ethanol solution, cosolvent, diluent or filler, disintegrating agent, taste correcting agent, glidants or dispersing agent, effervescing agent, lubricant in proportion, its step is that firstly adding ebastine into ethanol solution, and then adding cosolvent organic acid, leading it to dissolve entirely; secondly mixing the diluent or filler, disintegrating agent, taste correcting agent, effervescing agent with dispersing agent, to obtain a mixer; third mixing the front two, preparing soft material, preparing granules, then adding disintegrating agent, effervescing agent, taste correcting agent, glidants and lubricant, tabletting or filling capsules, packing to obtain a solid oral preparation. The present invention preparing oral disintegrable tablet, dispersing tablet have short disintegrating time, good dispersing state. The obtained oral disintegrable tablet, dispersing tablet and chewing tablet have good taste and mouth feel, the obtained solid oral preparations dissolving out are all rapid. The method is easy, simple operation, without needing special equipment, and lower production cost.
Description
technical field [0001] The present invention relates to the pharmaceutical field, more specifically to a solid oral preparation of ebastine (including orally disintegrating tablets, chewable tablets, dispersible tablets and capsules), and also to a preparation method for the solid oral preparation of ebastine. The application of ebastine solid oral preparations in the field of allergic diseases, such as urticaria, allergic rhinitis, eczema, dermatitis, prurigo, pruritus, etc. Background technique [0002] Ebastine (EBA for short) is a new long-acting non-sedating second-generation histamine H 1 receptor antagonists. This product is mainly metabolized into carbastine (also known as caristine carebastine) in the body, which has a negative effect on histamine H 1 The receptor has a selective antagonistic effect, can inhibit the release of histamine, and has an effect on the H in the central nervous system. 1 Receptor antagonist and anticholinergic effects are weak. Preclini...
Claims
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Application Information
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