Annonaceousacetogenins compounds and preparation method thereof
A kind of technology of annua lactone and compound, which is applied in the field of tetrahydrofuran-containing annua lactone compound and its preparation, and can solve problems such as unsatisfactory performance.
Inactive Publication Date: 2008-04-30
EAST CHINA UNIV OF SCI & TECH
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Abstract
The invention relates to annonaceous acetogenin compound including tetrahydrofuran and the preparation method thereof. The structure of the annonaceous acetogenin compound is shown as the formula A or the formula B. The method to prepare the annonaceous acetogenin compound comprises the main steps that: under the condition of the existence of lithium alkyl, the ring opening coupling reaction is operated through chiral double tetrahydrofuran alkyne compound with a blocking group and chiral epoxy lactone compound with a blocking group to obtain intermediate compound, the deprotection reaction and the electronation reaction are operated in sequence to the intermediate compound to obtain an object. Compared with the prior annonaceous acetogenin compound including the tetrahydrofuran, the antineoplastic activity of the annonaceous acetogenin compound including the tetrahydrofuran prepared by the invention is obviously improved. In the formula A and the formula B, m is 2 to 10, n is 5 to 8.
Application Domain
Organic chemistryAntineoplastic agents
Technology Topic
Lactone CompoundLithium +8
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