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Method for extracting salvianolic acid B and hydroxysafflor Yellow A and preparation method of Danhong for injection

An extraction method and a technology for hydroxysafflower, applied in the field of preparation of Danhong preparations, can solve the problems of incomplete extraction of salvianolic acid B and hydroxysafflor yellow A, poor stability of Danhong injection, inconvenient transportation and storage, etc. problem, to achieve the effect of easy regeneration, good elution effect and long service life

Active Publication Date: 2008-04-30
哈药集团中药有限公司
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AI Technical Summary

Problems solved by technology

[0003] The present invention aims to solve the problem of incomplete extraction of salvianolic acid B and hydroxysafflower yellow A in the existing extraction methods of salvianolic acid B and hydroxysafflower yellow A and the mixed extraction process used in the preparation of Danhong injection. The content of the extracted active ingredients is low, the color will become darker and precipitate after long-term storage, and the stability of the prepared Danhong injection is poor, and the transportation and storage are inconvenient. Therefore, salvianolic acid B and hydroxysafflower yellow are provided. Extraction method of pigment A and preparation method of Danhong for injection

Method used

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specific Embodiment approach 1

[0018] Specific embodiment one: the extraction method of the salvianolic acid B of the present embodiment is carried out as follows: one, first, add the ethanol of 8~18 times of the quality of the salvia miltiorrhiza to the decoction pieces of the salvia miltiorrhiza medicinal material, the mass concentration is 35%~60% and the volume is Soak in hydrochloric acid with ethanol volume 1‰~4‰ and concentration of 1mol / L for 1~2 hours, then reflux extraction for 1.5~3 hours, filter out the Danshen medicinal liquid, and then add 6~16 times the mass of the medicinal residue and the concentration of the medicinal residue to the medicinal residue. 35% to 60% ethanol and hydrochloric acid with a volume of 1‰ to 4‰ of ethanol and a concentration of 1mol / L, reflux extraction for 1 to 2 hours, filter out the Danshen medicinal liquid, combine the extracted Danshen medicinal liquid twice, and then Concentrate under reduced pressure into Danshen Qingpao with a relative density of 1.16-1.24; 2....

specific Embodiment approach 2

[0020] Specific embodiment 2: the difference between this embodiment and specific embodiment 1 is: in step 1, add 12 to 14 times the mass of salvia miltiorrhiza to the decoction pieces of salvia miltiorrhiza, and ethanol with a mass concentration of 45% to 55%, and the volume is the ethanol volume Soak in 2‰-3‰ hydrochloric acid with a concentration of 1mol / L for 1.2-1.8 hours, and then reflux extraction for 2-2.5 hours. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0021] Specific embodiment three: the difference between this embodiment and specific embodiment one is: in step 1, first add Danshen decoction pieces quality 13 times to Danshen medicinal material decoction pieces, mass concentration is 50% ethanol and volume is ethanol volume 2.5‰, concentration is Soak in 1mol / L hydrochloric acid for 1.5 hours, then reflux for 2.2 hours. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

The invention discloses an extraction method of salvianolic acid B and hydroxy safflor yellow A as well as a preparation method of danhong for injection, and relates to the extraction method of the salvianolic acid and the hydroxy safflor yellow as well as the preparation method of the danhong preparation. The invention solves the problems that the extraction of the salvianolic acid B and the hydroxy safflor yellow A is not thorough, and the transportation and the storage of the prepared danhong injection are inconvenient. The salvianolic acid B of the invention is extracted according to the following steps: backflow, acidification and adsorption; thus the salvianolic acid B is obtained. The hydroxy safflor yellow A of the invention is extracted according to the following steps: boil out, acidification and adsorption; thus the hydroxy safflor yellow A is obtained. The danhong for injection is extracted according to the following steps: compounding ratio and standing, filtrating and lyophylization; thus the danhong for injection of the invention is obtained. The extraction rate of the salvianolic acid B and the hydroxy safflor yellow A of the invention is high, and the transportation and the storage of the prepared danhong injection are convenient.

Description

technical field [0001] The invention relates to a method for extracting salvianolic acid and hydroxysafflower yellow and a method for preparing danhong preparation. Background technique [0002] Danhong Injection announced in the "National Drug Standards (Trial) Promulgation Document" is a traditional Chinese patent medicine with good clinical efficacy and a history of more than 20 years. It is mainly used for important emergencies of cardiovascular and cerebrovascular diseases For treatment, the common ones are coronary heart disease, angina pectoris, etc., and it can also treat chest obstruction caused by congestion and occlusion, that is, stroke. The existing methods for extracting salvianolic acid B and hydroxysafflower yellow A are incomplete in extracting salvianolic acid B and hydroxysafflower yellow A. Moreover, the existing Danhong injection (Ministerial Standard WS-11220 (ZD-1220)-2002) adopts a mixed extraction process in the preparation process, and the extracte...

Claims

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Application Information

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IPC IPC(8): C07D307/80C07D309/10A61K36/53A61K36/286
Inventor 李殿明付饶任瑞涛吴志军秦绪江刘占滨王英新马志强
Owner 哈药集团中药有限公司
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