Arificial tears containing trehalose as well as preparation and application method thereof

Abstract

The invention relates to artificial tear containing trehalose and the preparation and application method, which pertains to the technical field of pharmaceutical manufacture. The main component of the invention is the trehalose, the basic composition of the artificial tear is the trehalose, simulating mucin protein and conventional ophthalmic pharmaceutical excipients; the weight ratio of the three is that 0.3 to 97 percent trehalose, 0.3 to 97 percent simulating mucin protein and 2 to 98 percent conventional ophthalmic pharmaceutical excipients. The pH and the osmotic pressure of the artificial tear of the invention are equivalent to physiologic tear, the invention contains rich electrolyte ions, the type and the content of the ions are equivalent to the physiologic tear, and the invention can be used in the treatment of dry eye syndrome and the adjuvant treatment of diseases which are caused by other dry eye syndromes. At the same time, the invention can be used as the drug delivery system of various ophthalmic drugs.

Description

technical field [0001] The invention relates to artificial tears containing trehalose and a preparation method thereof, belonging to the technical field of medicine preparation. Background technique [0002] Dry eye is one of the most common diseases in ophthalmology. The typical symptoms are local eye irritation, photophobia, blurred vision or vision fluctuations. In some severe cases, it can cause severe vision loss or even blindness. The pathogenesis of dry eye is more complicated, and the lipid abnormality of the tear film, the water layer abnormality, the mucus layer abnormality and the ocular surface abnormality can all cause dry eye syndrome. Autoimmune diseases - Sjögren's syndrome may also have dry eye syndrome, in which the reduction of tear water layer secretion is more common. [0003] At present, the most important method for the treatment of dry eyes is tear replacement therapy, that is, local use of artificial tears to improve ocular surface moisture and lubr...

AI Technical Summary

Problems solved by technology

Since the tears secreted by the human body contain complex components such as water, electrolytes, proteins, and lipids, there are few commercially available artificial tears that can truly simulate the three-layer structure of the tear film.

Looking at the artificial tears developed at home and abroad at present, the permeability of corneal epithelium is significantly reduced within 2 weeks after the administration of some, but the permeability will not be further reduced when the administration is continued until 4 weeks; some continuous use can improve dry eye disease Symptoms, but discontinuation of use may cause corneal ulcers and abnormal and reduced corneal goblet cell differentiation; some patients may experience discomfort or even allergic reactions after clinical use