Hydroxyl benzoic anhydride dimer compound, preparation method and uses thereof

A technology of hydroxybenzoic anhydride dimer and tetrahydroxydibenzoic anhydride is applied in the fields of hydroxybenzoic anhydride dimer compound, preparation and use, and can solve problems such as low activity and instability
CN101200426AActive Publication Date: 2008-06-18SHENGHUA GUANGZHOU PHARMA SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENGHUA GUANGZHOU PHARMA SCI & TECH
Publication Date
2008-06-18

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Abstract

The present invention discloses symmetric and asymmetric m-hydroxybenzoic acid dimer compounds with constitutional formula (I), and as well as a method of the preparation of and the function of such products. Basic framework m-hydroxybenzoic acid and as well as hydroxybenzoic acid replaced by the same or different hydroxyl groups are condensed into m-hydroxybenzoic acid dimer compound with a parent nucleus symmetric structure and with the replacement of the same or different number of hydroxyl groups, the pharmacological test proves that the product has the activities of anti-human papillomavirus, herpes virus and resist HIV-1 integrase inhibitors; the product is capable to resist the virus that can integrally enter the chromosome of human cell, inhibit the breeding of the virus that integrally enter into the chromosome, prevent the relapse of virus infection; in addition, the product has antitumor activity.
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Description

technical field

[0001] The present invention relates to a hydroxybenzoic anhydride compound with a symmetrical or asymmetrical structure, more specifically, to an acid anhydride dimer compound formed by condensation of benzoic acid substituted with two or more hydroxyl groups or the like The compound, its preparation method, and its use as a high-efficiency HIV-1 integrase inhibitor for the preparation of anti-human papillomavirus, herpes virus, HIV and anti-tumor drugs. Background technique

[0002] HIV (HIV), herpes virus (HSV), and human papillomavirus (HPV) all have the characteristics of integrating into the chromosomes of human cells, but each has different genetic and metabolic characteristics.

[0003] HIV-1 is the virus that causes AIDS, which encodes three enzymes: reverse transcriptase (reverse transcriptase, RT,), protease (Protease, PR) and integrase (Integrase, IN). These three enzymes are essential enzymes necessary for HIV replication and infection. At pres...

Claims

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