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Liquid composite containing salbutamol sulfate and ambroxol hydrochloride

A technology of salbutamol sulfate and ambroxol hydrochloride, which is applied in the field of liquid pharmaceutical compositions containing salbutamol sulfate and ambroxol hydrochloride, can solve problems such as side effects and effects, and achieve good stability

Active Publication Date: 2011-01-12
万特制药(海南)有限公公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The addition of these additives, long-term use has certain side effects on the human body, especially on children.

Method used

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  • Liquid composite containing salbutamol sulfate and ambroxol hydrochloride
  • Liquid composite containing salbutamol sulfate and ambroxol hydrochloride
  • Liquid composite containing salbutamol sulfate and ambroxol hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016]

[0017] Preparation process: take by weighing albuterol sulfate, sucralose, orange flavor and glycerin in 30000ml of water, stir and dissolve in 30000ml of water, adjust the pH value to 3.0-4.0, to obtain solution I; measure 30000ml of purified water, add ambroxol hydrochloride, Sorbitol and sodium chloride are stirred and dissolved, and the pH value is adjusted to 2.5-4.5 to obtain solution II; Mix solutions I and II, add water to the full volume, use a sand filter rod with a pore size of 0.8 microns to filter the solution, and combine the filtrates to obtain The semi-finished solution is filled and sealed after passing the inspection.

Embodiment 2

[0019]

[0020] Preparation process: take by weighing albuterol sulfate, sucralose, orange flavor and glycerin in 30000ml of water, stir and dissolve in 30000ml of water, adjust the pH value to 3.0-4.0, to obtain solution I; measure 30000ml of purified water, add ambroxol hydrochloride, Sorbitol and sodium chloride are stirred and dissolved, and the pH value is adjusted to 2.5-4.5 to obtain solution II; mix solutions I and II, add water to the full volume, use a sand filter rod with a pore size of 0.8 microns to filter the solution, and combine the filtrates to obtain a semi-finished product Solution, after passing the inspection, potting.

Embodiment 3

[0022]

[0023] Preparation process: take by weighing albuterol sulfate, sucralose, orange flavor and propylene glycol in 30000ml of water, stir and dissolve in 30000ml of water, and adjust the pH value to 3.0-4.0 to obtain solution I; measure 30000ml of purified water, add ambroxol hydrochloride, Sorbitol and sodium chloride, stir to dissolve, adjust the pH value to 2.5-4.5 to obtain solution II; add solution I and solution II, add water to the full volume, use a sand filter rod with a pore size of 0.8 microns to filter the solution, and combine the filtrates , to obtain a semi-finished solution, which is filled and sealed after passing the inspection.

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Abstract

The invention discloses a drug composition taking salbutamol sulfate and ambroxol hydrochloride as active ingredient, also the composition contains a stabilizer, a PH modifying agent and a flavoring agent. However, the composition does not contain an antioxidant or a metal ion complexing agent. The drug composition is used for curing respiratory diseases such as bronchitis and asthma, etc.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition for treating acute and chronic bronchitis, general asthma and acute and chronic bronchial diseases with poor secretion and bronchospasm, in particular to a medicine containing albuterol sulfate and ambroxol hydrochloride Liquid pharmaceutical composition. Background technique [0002] Salbutamol sulfate is a selective β2-adrenoceptor agonist. It can selectively act on bronchial smooth muscle β2 adrenergic receptors, and has weak stimulatory effect on myocardial β1 receptors. Ambroxol hydrochloride is bromcycline, which is a mucolytic agent and is used for the treatment of respiratory disorders caused by mucus blockage in the bronchi due to thick mucus or increased mucus. It can increase the secretion of serous glands in the respiratory mucosa and regulate the function of alveolar macrophages. Symptoms such as cough and sputum in the respiratory tract often occur successively, and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/137A61K9/08A61P11/00A61P11/06
Inventor 袁筝
Owner 万特制药(海南)有限公公司
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