Chinese traditional medicine preparation for antiatheroscloresis and liver-protection, and preparingng method thereof

A traditional Chinese medicine preparation and blood lipid-lowering technology, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., and can solve problems such as elevated blood sugar and liver function damage.

Active Publication Date: 2008-07-30
GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine statins and fibrates are more effective in treating hyperlipidemia and other symptoms, but at present, western medicine can cause blood sugar elevation, nausea, diarrhea and liver function damage while lowering blood lipids.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Ligustrum lucidum medicinal material 2000g, tea polyphenols 20g, olive oil 250g, perilla seed oil 250g, beeswax 1.5g

[0076]Take the Ligustrum lucidum medicinal material that is crushed into coarse powder, and use ethanol to reflux extract three times, add 7 times the amount of ethanol for extraction for 1.5 hours each time, combine the extracts, filter, and concentrate the filtrate under reduced pressure to 6 times the weight of the Ligustrum lucidum medicinal material, add Activated charcoal with 15% weight of Ligustrum lucidum medicinal material, heated and refluxed for 5 hours, filtered, and the filtrate was concentrated under reduced pressure to an extract with a relative density of 1.10 to 1.20 at 60°C, added 8 times the amount of water-soluble extract, adjusted with 20% hydrochloric acid solution to pH 1.5, fully stirred, left to stand for 24 hours, filtered, the precipitate was washed with water to pH 7.0, and dried under reduced pressure to obtain a ...

Embodiment 2

[0077] Example 2: Ligustrum lucidum medicinal material 2500g, tea polyphenols 15g, olive oil 200g, perilla seed oil 200g, beeswax 2g

[0078] Take the Ligustrum lucidum medicinal material that is crushed into coarse powder, and extract it three times with ethanol under reflux, add 8 times the amount of ethanol for extraction for 1.5 hours each time, combine the extracts, filter, and concentrate the filtrate under reduced pressure to 8 times the weight of the medicinal material Ligustrum lucidum, add Activated carbon with 20% of the weight of Ligustrum lucidum medicinal material, heated and refluxed for 4 hours, filtered, the filtrate was concentrated under reduced pressure to an extract with a relative density of 1.10-1.20 at 80°C, added 8 times the amount of water-soluble extract, and added 3-7% clarified agent (W / V), fully stirred, allowed to stand for 24 hours, filtered, and dried under reduced pressure to obtain light brown Ligustrum lucidum extract. Add Ligustrum lucidum ...

Embodiment 3

[0080] Example 3: Ligustrum lucidum medicinal material 3000g, tea polyphenols 10g, olive oil 230g, perilla seed oil 230g

[0081] Take the Ligustrum lucidum medicinal material that is crushed into coarse powder, extract it three times with ethanol under reflux, add 6 times the amount of ethanol for extraction for 1.5 hours each time, combine the extracts, filter, and concentrate the filtrate under reduced pressure to 4 times the weight of the medicinal material Ligustrum lucidum, add Activated carbon with 10% of the weight of Ligustrum lucidum medicinal material, heated and refluxed for 6 hours, filtered, the filtrate was concentrated under reduced pressure to an extract with a relative density of 1.10 to 1.20 at 60°C, added 6 times the amount of water-soluble extract, stirred well, and used Adjust the pH of the hydrochloric acid solution to 2.0, stir well, add 3% NaCl (W / V) and stir to dissolve, let it stand for 24 hours, filter, wash the precipitate with water to pH 7.0, and ...

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PUM

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Abstract

The invention provides a Chinese medicine preparation for reducing blood lipid and protecting livers and the preparation method thereof. The preparation utilizes ligustrum lucidum and tea polyphenol as main effective components which are mixed with olive oils and perillaseed oils to prepare various preparations of pharmaceutical importance according to conventional processes. The Chinese medicine preparation of the invention can not only significantly reduce blood lipid but also protect livers.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine preparation for lowering blood fat and protecting liver and a preparation method thereof. Background technique [0002] Hyperlipidemia refers to a disease in which blood lipid components such as cholesterol, triglycerides, phospholipids and unlipidated fatty acids in plasma increase. Hyperlipidemia is caused by eating too much food containing fat and cholesterol, and it is also related to genetic factors. The "lipids" in plasma are mainly cholesterol and triglycerides, which do not exist alone, but are transported in the form of apolipoproteins, which mainly include chylomicrons (CM), very low-density lipoproteins (VLDL) , intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Hyperlipidemia is a risk factor for systemic atherosclerosis, such as susceptibility to coro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/63A61K9/14A61K9/16A61K9/20A61K9/48A61K47/42A61P3/06A61P1/16A61K31/352
Inventor 蒋朝晖麻秀萍王晓春周宁谭静冯泽熹杨昌生曾香兰
Owner GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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