Pig transmissible gastroenteritis virus vaccine strain and application thereof
An attenuated vaccine and infectious technology, which are applied to the attenuated vaccine strain of porcine infectious gastroenteritis and Chinese virus and its application, and the field of attenuated vaccine strains to achieve the effect of good safety.
Active Publication Date: 2010-08-18
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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Problems solved by technology
There is still a lack of an effective vaccine against porcine transmissible gastroenteritis virus
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The invention discloses a transmissible gastroenteritis virus (H) attenuated vaccine strain and the application. The microorganism preservation number of the attenuated vaccine strain of the invention is CCTCC-V200609. The safety of attenuated strain TGEV of the invention is excellent, which has excellent immune protective rate. The attenuated strain of the invention can be applied in preparing diagnostic reagent for diagnosing transmissible gastroenteritis, and also can be applied in preparing single vaccine or mixed vaccine (active or inactivated vaccine) and the like.
Description
technical field The invention relates to an attenuated vaccine strain, in particular to an attenuated vaccine strain for porcine transmissible gastroenteritis sinovirus and an application thereof, belonging to the field of biomedicine. Background technique Porcine transmissible gastroenteritis is a highly contagious acute viral infectious disease of the digestive tract caused by porcine transmissible gastroenteritis virus. It is characterized by vomiting, watery diarrhea, dehydration and high mortality in piglets under 10 days of age. The disease is susceptible to pigs of all ages, but piglets under 2 weeks of age are the most susceptible, and the case fatality rate can be as high as 100%. The pathogen of this disease is mainly Transmissible gastroenteritis virus (TGEV), which belongs to the member of the genus Coronavirus (Coronavirus) of the family Coronaviridae of the order Nidovirales. Capsule, various shapes, spherical or ellipsoid, 90-160nm in diameter, covered with...
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IPC IPC(8): C12N7/00C12N15/50A61K39/225A61K35/76A61P31/12G01N33/569
Inventor 冯力王承宝时洪艳陈建飞佟有恩王明马思奇
Owner HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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