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Hemostasia article and method for preparing same

A manufacturing method and a technology for hemostatic substances, which are applied in the field of hemostatic substances and their manufacture, can solve the problems of low connection strength of the hemostatic substances, collapse and disperse of chitosan, and reduce the effect of the hemostatic substances, and achieve complete cross-linking effect, low price, and low cost. easy to achieve effect

Inactive Publication Date: 2008-09-03
BIO SPONGE TECH
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Problems solved by technology

[0004] However, chitosan still has the following disadvantages in the preparation process: the hemostatic material made of only chitosan as the hemostatic material has too low bonding strength, and the material will disperse immediately
However, water is generally used as the main solvent for the preparation of glutaraldehyde. However, chitosan will collapse and disperse in aqueous solution, thereby reducing its cross-linking effect with chitosan.

Method used

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  • Hemostasia article and method for preparing same
  • Hemostasia article and method for preparing same

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Embodiment Construction

[0022] The preferred embodiment of the hemostatic material manufacturing method of the present invention is shown in Fig. 1, which includes:

[0023] A. Preparation solution: In this embodiment, 2% high molecular weight (molecular weight is 300,000) chitosan and 2% low molecular weight chitosan solution (molecular weight is 70,000) are prepared respectively with 0.1N acetic acid as solvent ), this step takes a day for the chitosan to dissolve completely. And apply stirring to help it dissolve. The stirring method is to use a stirrer to match the resistance of the object to be stirred. Use a fine stirring bar with a specification of 2 to 3 cm. The height of the stirred solution is less than or equal to 4 to 5 cm to have a better stirring effect. .

[0024] B. Inject into the container: Before this step, filter the impurities in the solution with a filter, and measure the chitosan solution with a syringe. Since chitosan is easy to thicken, it is necessary to measure slowly and ...

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Abstract

The invention discloses a hemostatic matter and a manufacturing method thereof, and relates to the surgical hemostatic field. The high molecular weight chitosan and the chitosan with high solubility and low molecular weight are mixed by a specific proportion, and a special glutaraldehyde organic solution is utilized for carrying out the cross-linking reaction, thus preparing the hemostatic matter which is easy to be fully reacted with a cross-linking agent and has great hemostatic property and excellent connection strength simultaneously.

Description

【Technical field】: [0001] The invention discloses a hemostat and a manufacturing method thereof, and relates to the technical field of surgical hemostasis. 【Background technique】: [0002] Generally, during cardiac catheterization, after the treatment catheter is pulled out, it is necessary to compress the wound for 5-30 minutes until the bleeding stops, and then use a bandage to pressurize. Press for 6-8 hours, and during the process of hemostasis, the patient needs to lie flat completely without bending the thigh, and maintain this fixed position for 6-12 hours. However, this hemostatic method has a poor hemostatic effect and is prone to bleeding. In this case, it is very effective to provide a hemostat that can promote blood coagulation reaction, form thrombus quickly and prevent bleeding when it comes into contact with the bleeding wound surface. It can not only shorten the operation time, but also prevent postoperative bleeding. The rebleeding is also helpful for the ...

Claims

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Application Information

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IPC IPC(8): A61L15/28
Inventor 张淑真郭士民
Owner BIO SPONGE TECH
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