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Silk fibroin small diameter blood vessel

A silk fibroin, small-caliber technology, applied in the direction of blood vessels, human tubular structures, etc., can solve the problems of limited application scope, insufficient mechanical properties, etc., to avoid the use of organic solvents, time-consuming, and easy to process.

Inactive Publication Date: 2008-09-17
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the regenerated silk fibroin film prepared by the existing flow-through method has shortcomings in terms of mechanical properties, which largely limits its application range.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Apply the prepared solution evenly on the outer wall of the metal tube, the outer diameter of the metal tube is 6mm, dry naturally, keep the metal tube rotating at a rotation speed of 20rpm, after the solution is dried, cool and remove the film to obtain a single-layer silk tube with an inner diameter of 6mm .

Embodiment 2

[0029] Apply the prepared solution evenly on the outer wall of the metal tube, the outer diameter of the metal tube is 4mm, heat it with a heating rod, keep the metal tube rotating, the rotation speed is 20rpm, after the solution is dried, soak it in water and take off the film to obtain a single layer with an inner diameter of 4mm silk fibroin tube.

Embodiment 3

[0031] The preparation process of silk fibroin tube is as follows:

[0032]Apply the prepared solution evenly on the outer wall of the metal tube, the outer diameter of the metal tube is 4mm, heat the heating rod, keep the metal tube rotating, the rotation speed is 50rpm, after the solution is dried; apply the solution on the outer wall of the metal tube again, and heat and dry at 50 degrees . This process can be repeated N times as needed to reach the desired thickness. After the solution is completely dry, soak the metal tube in water to take the film. The thickness of the obtained silk fibroin tube increases with the number of layers.

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Abstract

The invention relates to the preparation and application of a silk fibroin protein tube, belonging to biomedical materials field. The invention is characterized in that (1) the modified anticoagulation silk fibroin protein solution is coated on the specific pipe and profile evenly, the treating and drying is processed, and the silk fibroin protein tube with special shape is acquired, (2) the process of (1) can be repeated to process multiple coating according to the thickness and mechanical property requirements, (3) the immersion treatment in the solution is processed to make silk fibroin protein tube soft, and the silk fibroin protein tube and the profile material can be taken down from the pipe, and (4) the product is arranged at certain humidity and temperature for conservation. The silk fibroin protein tube has the advantages of free of adhesion, no residue of organic chemicals, preparing pipe directly, no obvious stress drawback, disclosing the relation between the silk fibroin tube preparation technology and the mechanical property, controllable pipe diameter, length and thickness, good mechanical property and biocompatibility of prepared pipe, simple and easy practice of preparation process, low cost, and being applicable to commercial production.

Description

technical field [0001] The invention is a new method for preparing silk fibroin small-diameter artificial blood vessels with good biocompatibility, and relates to the field of biomedical materials. Background technique [0002] Around the world, tens of thousands of people have to replace certain parts of their organs every year due to various reasons such as aging, damage, and disease, and the blood vessels in the human body are no exception. However, due to the rejection of allogeneic blood vessels and the limitation of autologous blood vessels, most of the blood vessels used in transplantation come from artificial blood vessels. For this reason, it is necessary to carry out the development of medical artificial blood vessels. At present, the most widely used fiber materials for artificial blood vessels are polyester and expanded polytetrafluoroethylene, which are made by warp knitting or weaving. This linear or cross-shaped artificial blood vessel is woven on a narrow l...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61F2/06
Inventor 曹传宝王玉晶马西兰周涓常婧婧张兴华
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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