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Composition of Prunella plant extracts, preparation and pharmaceutical use thereof

A plant extract, the technology of Prunella genus, applied in the field of composition, preparation and medicinal application of the plant extract of Prunella genus, can solve the problems such as the material basis is not very clear

Active Publication Date: 2008-10-01
上海硕方医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although there are many reports on the pharmacological effects of Prunella vulgaris, the material basis of its pharmacological effects, that is, which chemical parts are related to which pharmacological effects, is not very clear

Method used

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  • Composition of Prunella plant extracts, preparation and pharmaceutical use thereof
  • Composition of Prunella plant extracts, preparation and pharmaceutical use thereof
  • Composition of Prunella plant extracts, preparation and pharmaceutical use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The preparation method of the composition of Prunella vulgaris extract:

[0063] (1) Prunella vulgaris fruit ears 500g, adding weight percentage concentration is that 80% ethanol is extracted three times by heating and refluxing, each time is 3500ml, and the time is successively 2, 1.5, 1 hour; Merge three extracts, adopt the method of decompression concentration to reclaim ethanol , concentrated to about 500ml; stand overnight at room temperature, filter, filter residue A and filtrate A are used separately, filter residue A is about 12g after drying;

[0064] (2) Filter residue A is dissolved in about 100ml of 80% ethanol with a concentration of 80% by weight, add 50g of 100 mesh diatomaceous earth to mix the sample for adsorption, evaporate to dryness under reduced pressure and carry out column chromatography, elute with 500ml of petroleum ether, recover petroleum ether, and discard the residue , then elute with 500ml of ethanol, and collect the total triterpene eluat...

Embodiment 2

[0069] The preparation method of the composition of Prunella vulgaris extract:

[0070] (1) 100 g of Prunella vulgaris fruit ears were extracted three times with 80% ethanol by weight percentage, 700 ml each time, and the time was 2, 1.5, and 1 hour in sequence. Combine the three extracts, recover ethanol by concentrating under reduced pressure, and concentrate to about 100ml; let it stand overnight at room temperature, filter, filter residue A and filtrate A are used separately, and filter residue A is about 2.5g after drying;

[0071] (2) The filter residue A is dissolved in about 20ml of 80% ethanol with a concentration of 80% by weight, add 100 mesh diatomaceous earth 10g to mix the sample for adsorption, evaporate the ethanol to dryness, evaporate to dryness under reduced pressure and perform column chromatography, elute with 100ml of petroleum ether, and recover petroleum ether, discard the residue, then elute with 100ml of ethanol, and collect the total triterpene eluat...

Embodiment 3

[0076] The preparation method of the composition of Prunella vulgaris extract:

[0077] (1) 100 g of Prunella vulgaris fruit ears were extracted three times with 80% ethanol by weight percentage, 700 ml each time, and the time was 2, 1.5, and 1 hour in sequence. Combine the three extracts, recover ethanol by concentrating under reduced pressure, and concentrate to about 100ml; let it stand overnight at room temperature, filter, filter residue A and filtrate A are used separately, and filter residue A is about 2.6g after drying;

[0078] (2) The filter residue A is dissolved in about 20ml of 80% ethanol with a concentration of 80% by weight, add 100 mesh diatomaceous earth 10g to mix the sample for adsorption, evaporate the ethanol to dryness, steam under reduced pressure to carry out column chromatography, elute with 100ml of petroleum ether, and recover petroleum ether, discard the residue, then elute with 100ml of ethanol, and collect the total triterpene eluate;

[0079] (...

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Abstract

The invention relates to a composition of prunella plant extracts, a preparation method and pharmic use of the composition. The activity components of the composition of the prunella plant extracts are composed of total triterpenes and total phenolic acid, wherein, the extract of the total triterpenes contains 10.0 to 45.0 wt percent of ursolic acid and 50.5 to 98.0 wt percent of the total triterpenes; the extract of the total phenolic acid contains 21.5 to 65.0 wt percent of rosmarinic acid and 70.5 to 99.0 wt percent of the total phenolic acid. The invention also relates to a preparation method and medical application of the composition.

Description

technical field [0001] The invention relates to an extract containing active ingredients extracted from plants, a preparation method of the extract and a new application of the extract in medicine. In particular, it relates to a composition obtained by extracting an extract containing an active ingredient from a plant of the genus Prunella. The present invention also relates to the preparation method of the composition of the extracts and their medicinal use. Background technique [0002] There are 15 species of Prunella in the Labiatae family in the world, and the main ones produced in China are: Prunella vulgaris L., Prunella vulgaris L.var.leucantha Schur sec.bailey, Prunella vulgaris L. var.leucantha (Barton) Fernald, mountain spinach P.asiatica Nakai., its variant P.asiatica Nakai var.albiflora (koidz.) Nakai, P. .) Jacq. Commonly used as a traditional Chinese medicine is the dried mature ear or whole plant of Prunella vulgarls L., which has the effects of clearing f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/536A61K9/20A61K9/48A61P3/10A61P5/14A61P9/10A61P9/12A61P15/00A61P15/14A61P31/04A61P31/06
Inventor 秦继红
Owner 上海硕方医药科技有限公司
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