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Physiotherapy electrode plate clamping self-pasting medicine carrying membrane and manufacture method thereof

A drug-loaded film and self-adhesive technology, which is applied in the direction of electrodes, electrotherapy, and pharmaceutical formulations, can solve the problems of reducing the adhesive performance of conductive adhesives, reducing application flexibility, and increasing production costs, so as to overcome the problem of high price, The effect of reducing competition transmission and reducing the cost of use

Inactive Publication Date: 2008-10-01
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This electrode improves the transdermal penetration of the drug by improving the contact between the drug solution and the skin, but its disadvantage is that the drug solution is easy to seep out, and once it seeps out to the surface of the conductive adhesive, it will greatly reduce the sticking performance of the conductive adhesive
In addition, the electrode must use electrode materials that do not change the pH of the surrounding environment during iontophoresis, such as silver / silver chloride electrodes and platinum electrodes, which reduces its application flexibility and increases production costs

Method used

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  • Physiotherapy electrode plate clamping self-pasting medicine carrying membrane and manufacture method thereof
  • Physiotherapy electrode plate clamping self-pasting medicine carrying membrane and manufacture method thereof
  • Physiotherapy electrode plate clamping self-pasting medicine carrying membrane and manufacture method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Preparation of buffer layer gel material

[0030] 2 grams of chitosan with a molecular weight of 300,000 and 3 grams of polyvinyl alcohol 17-99 were dissolved in 100 mL of lactic acid solution with a mass concentration of 2% and 30 mL of distilled water, and then the two solutions were mixed until uniform. While stirring, 32 grams of mass concentration are 25% gelatin (molecular weight is 150,000) solution, 40mL pH6.5 acetate buffer solution, 50 grams of mass concentration are 30% maltooligosaccharide, 50 grams of mass concentration are 40% Sucrose oligosaccharides, 3 grams of glycerin, 0.1 grams of sodium benzoate and 10 grams of KCl solution with a mass concentration of 10% were added to the mixed solution, thoroughly mixed at 40-45° C. and then degassed.

[0031] 2. Preparation of drug release layer gel material

[0032] Dissolve 2 grams of carbomer 940 in 50 mL of distilled water, add 4 grams of triethanolamine under stirring to gel the carbomer solution, and mi...

Embodiment 2

[0036] The preparation process of the buffer layer gel material is the same as that of Example 1, except that the pH6.5 acetate buffer solution is changed to the pH7.2 phosphate buffer solution.

[0037] The preparation process of the drug release layer gel material is the same as that of Example 1.

[0038] The preparation process of the physiotherapy electrode sheet sandwiching the self-adhesive drug-loaded film is the same as that of Example 1. In the physiotherapy electrode sheet sandwiched with the self-adhesive drug-loaded film, the thickness of the buffer layer is 0.5 mm, and the thickness of the drug-releasing layer is 0.5 mm. 0.5mm.

Embodiment 3

[0040] The preparation process of the buffer layer gel material is the same as that of Example 1, except that the pH6.5 acetate buffer solution is changed to the pH7.6 phosphate buffer solution.

[0041] The preparation process of the drug release layer gel material is the same as that of Example 1.

[0042] The preparation process of the physiotherapy electrode sheet sandwiching the self-adhesive drug-loaded film is the same as that of Example 1. In the physiotherapy electrode sheet sandwiched with the self-adhesive drug-loaded film, the thickness of the buffer layer is 0.5 mm, and the thickness of the drug-releasing layer is 0.5 mm. 0.5mm.

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Abstract

The invention relates to a physical therapeutic electrode slice which clamps a self-adhesive drug-loaded membrane and a preparation method thereof. The physical therapeutic electrode slice which clamps the self-adhesive drug-loaded membrane consists of an existing conductive electrode and the self-adhesive drug-loaded membrane clamped by a stripping layer, wherein, the self-adhesive drug-loaded membrane consists of a cushioning layer and a drug-release layer. The preparation method of the physical therapeutic electrode slice comprises three processes which are the preparation of gel material for the cushioning layer, the preparation of gel material for the drug-release layer and the preparation of the physical therapeutic electrode slice which clamps the self-adhesive drug-loaded membrane; besides, the gel material for the cushioning layer is essentially made from chitosan and polyvinyl alcohol, etc. and the gel material for the drug-release layer is essentially made from carbomer and alginic acid, etc. The physical therapeutic electrode slice can guarantee the stability of the environment of the drug carried by the slice and effectively reduces the competitive transfer of ion during the electric treatment process and improves the penetrating property through skin of the drug at the same time so as to improve curative effect. Besides, the physical therapeutic electrode slice which clamps the self-adhesive drug-loaded membrane has simple preparation method and great amount of drug loading, thereby being especially suitable for Western medicine and traditional Chinese medicine which are sensitive to pH value.

Description

technical field [0001] The invention relates to a physiotherapy electrode sheet sandwiching a self-adhesive drug-loaded film and a preparation method thereof, belonging to the physiotherapy electrode sheet technology. Background technique [0002] The modernization of traditional Chinese medicine is a strategic decision of our country, and drug delivery technology is a key technology and an effective way to realize the modernization of traditional Chinese medicine. External treatment of traditional Chinese medicine has a history of thousands of years in the development of traditional Chinese medicine, and its application involves the treatment of diseases such as surgery, orthopedics, and dermatology. Traditional traditional Chinese medicines for external treatment are mainly powders, ointments, pastes, etc. The main active ingredients of the medicines are stored in the cells, so the ingredients of the medicines are complex and the content of various ingredients is low. Slo...

Claims

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Application Information

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IPC IPC(8): A61N1/04A61N1/30A61N1/44A61M37/00A61K47/36A61K31/7048A61K36/00A61P17/00A61P31/10
Inventor 周雪琴刘东志姚康德赵田
Owner TIANJIN UNIV
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