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Process for preparing compound folium isatidis injection with membrane filter technique

A Folium Folium, membrane filtration technology, applied in the direction of medical formula, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of loss of active ingredients, increase pollution, consumption of organic solvents, etc., to reduce the loss of active ingredients, The effect of reducing pollution links and ensuring product quality

Inactive Publication Date: 2008-10-08
SHANDONG HUAXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] To sum up, the existing compound Folium Folium injection production technology is unreasonable, and the active ingredients are seriously lost; the tannin is not completely removed, which affects the clarity and causes pain during injection.
Consume a large amount of organic solvents, increase pollution, and seriously affect the quality of products
In view of the serious defects in the existing preparation methods of compound Folium Folium Injection, it is far from being able to meet the current requirements for the controllable quality of compound Folium Folium Injection and the safety and effectiveness of clinical medication.

Method used

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  • Process for preparing compound folium isatidis injection with membrane filter technique

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Take 1000g of Daqingye, 500g of honeysuckle, 250g of notopterygium, 250g of ginseng, and 250g of rhubarb, and add water to decoct three times. The amount of water added is 8, 6, and 6 times, each time for 1 hour. The filtrate is concentrated to 3 times the amount of Folium Folium medicinal material. Centrifuge the medicinal liquid at high speed (rotating speed is 18000r / min), filter it with a ceramic membrane with a molecular weight of 200,000, heat the filtrate to 80°C, adjust the pH value to 8.0 with 1% sodium hydroxide, cool to room temperature, and then use a ceramic membrane with a molecular weight of 10,000 Ceramic ultrafiltration membrane filtration, the ultrafiltrate is concentrated by 200nm nanofiltration membrane filtration to about 1 times the amount of Folium Folium, the content, resin, tannin, protein and other impurities are qualified, and a small test is done to detect abnormal toxicity, After the endotoxin is qualified, prepare potting as a spare solutio...

Embodiment 2

[0033] Take 1000g of Daqingye, 500g of honeysuckle, 250g of notopterygium, 250g of ginseng, and 250g of rhubarb, and add water to decoct three times. The amount of water added is 8, 6, and 6 times, each time for 1 hour. The filtrate is concentrated to 3 times the amount of Folium Folium medicinal material. Centrifuge the medicinal liquid at high speed (15000r / min), filter it with a hollow fiber membrane with a molecular weight of 150,000, heat the filtrate to 80°C, adjust the pH value to 8.0 with 1% sodium hydroxide, cool to room temperature, and then filter with a molecular weight of 10,000 The hollow fiber ultrafiltration membrane is used for filtration, and the ultrafiltrate is filtered with a 300nm nanofiltration membrane to concentrate to about 1 times the amount of Folium Folium. The detected content, resin, tannin, protein and other impurities are qualified. Do a small test and then detect abnormalities After the toxicity and endotoxin are qualified, it is prepared as a...

Embodiment 3

[0036] Take 1000g of Daqingye, 500g of honeysuckle, 250g of notopterygium, 250g of ginseng, and 250g of rhubarb, and add water to decoct three times. The amount of water added is 8, 6, and 6 times, each time for 1 hour. The filtrate is concentrated to 3 times the amount of Folium Folium medicinal material. Centrifuge the medicinal liquid at high speed (rotating speed is 10000r / min), filter it with a ceramic membrane with a molecular weight of 100,000, heat the filtrate to 80°C, adjust the pH value to 8.0 with 10% sodium carbonate, cool to room temperature, and then filter it with a ceramic ultrafiltration membrane with a molecular weight of 5000. Membrane filtration, the ultrafiltrate is filtered with a 150nm nanofiltration membrane and concentrated to about 1 times the amount of Folium Folium, the content, resin, tannin, protein and other impurities are tested to be qualified, and a small test is done to detect abnormal toxicity and endotoxin After passing the test, prepare p...

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Abstract

The invention discloses a process for preparing compound dyers woad leaf injection by membrane filtration technology. The process for preparing the compound dyers woad leaf injection by membrane filtration technology is as follows: according to the prescription of the compound dyers woad leaf injection, medicine materials are decocted; medicine liquid is condensed to three times as much as formula dosage, centrifuged, filtrated directly by the membrane with large pore size, filtrated by an ultrafiltration membrane and condensed by a nanofiltration membrane, thus extracting the compound dyers woad leaf injection. The process for preparing the compound dyers woad leaf injection has following characteristics: 1. heating process is reduced to decrease the loss of effective components; 2. the process is carried out at normal temperature to prevent phase transition and pollution; 3. the ethanol extraction process in conventional technology is replaced, so cost is saved and production is kept clean; 4. extraction period is shortened and pollution sections are reduced, thus offering technological insurance for the quality of products; 4. compared with content produced by prior art, the content is increased by over two times.

Description

(1) Technical field [0001] The invention relates to a preparation process of medicines, in particular to a process for preparing compound Folium Folium injection by membrane filtration technology. (2) Background technology [0002] Due to the rapid development of modern industry, global warming and pollution have followed. Especially in some developed areas, the incidence of viral infections and unknown high fever has been increasing year by year. In particular, the "SARS" in 2003 is still fresh in people's memory, and compound Folium Folium Injection has made great contributions during the "SARS" period. Compound Folium Folium Injection is a commonly used Chinese patent medicine for clearing away heat and detoxifying in clinical practice, and it is mainly used for the treatment of influenza and unknown high fever. Years of clinical experience have shown that this product has definite curative effect and few side effects. It also has a broad-spectrum antibacterial effect, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/08A61P31/16A61P29/00
Inventor 马继永张林张晓燕张涛王桂兰
Owner SHANDONG HUAXIN PHARMA
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