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Use of schisandra chinensis extract in anti-depression medicament

A Schisandra chinensis extract and antidepressant technology, applied in the field of medicine, can solve problems such as no antidepressant drugs, achieve the effects of less toxicity, relieve anxiety and pressure, and have wide application prospects

Active Publication Date: 2008-11-12
湖南省中药提取工程研究中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to our commonly used enzyme-reducing effect, the extracts of Schisandra chinensis (including Jiangxiling) are only effective in treating chronic liver diseases, and the development and application of Schisandra chinensis are mainly focused on new drugs for the treatment of hepatitis, but they have not been used. Reports on antidepressants

Method used

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  • Use of schisandra chinensis extract in anti-depression medicament
  • Use of schisandra chinensis extract in anti-depression medicament
  • Use of schisandra chinensis extract in anti-depression medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Soak Schisandra chinensis fruit in hot water to remove the peel, dry at 60°C, grind into powder, 100g of raw medicinal material, pass through a 40-mesh sieve, extract twice with 1000ml of 70% ethanol in a water bath at 80°C for 2 hours each time to obtain an extract, filter and concentrate into a paste , Dry under vacuum to obtain Schisandra extract (ie Schisandra extract).

Embodiment 2

[0016] Schisandra extract (i.e., Jiangxiling) capsules: Take 150g of Schisandra extract and appropriate amount of auxiliary materials, sieve, mix, put into capsules, and make 1000 capsules.

Embodiment 3

[0018] Schisandra Oral Liquid: The coarse powder of Schisandra chinensis is extracted with 30% ethanol. The ethanol is recovered, then diluted with water and flavored with stevioside to make a 10% liquid medicine.

[0019] The following is the experimental situation that the present invention can be used as an antidepressant drug.

[0020] 1. Mouse tail suspension experiment

[0021] 1.1 Animals

[0022] 40 healthy SD rats, male, clean grade, weighing 180-200 g; 40 healthy Kunming mice, male, clean grade, weighing 18-22 g. All were purchased from the Department of Experimental Zoology, Xiangya School of Medicine, Central South University, license number: SCXK (Xiang) 2003-0002. Raise in separate cages, 4 per cage. Room temperature 18-29°C, relative humidity 40%-70%, well-ventilated, quiet environment, drink cold boiled water.

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PUM

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Abstract

The invention relates to application of shizandra extract in antidepressant drugs. The invention provides use of the shizandra extract in the antidepressant drugs. The shizandra extract can be used as medicine for preventing or curing the depressive illness. The shizandra extract is pharmaceutical preparation which takes schisandrin, schisantherin, deoxyschizandrin, schisandrin B and so on as active ingredients. The preparation formulations which can be prepared by the shizandra extract are tablets, capsules, solution, suspension, injection or dropping liquid and so on. The shizandra extract is characterized by low toxicity and does not have the defects of calmness, telangiectasia ataxia, epilepsy induction and so on of antidepressants.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular it is a new application of Schisandra chinensis extract in antidepressant drugs. Background technique [0002] So far, the clinical application of schisandra extract is mainly focused on astringent and astringent, nourishing qi and promoting body fluid, tonifying kidney and calming heart. For chronic cough and shortness of breath, nocturnal spermatorrhea, enuresis, frequent urination, chronic diarrhea, spontaneous sweating, night sweats, thirsty body fluid wounds, shortness of breath and arteries, internal heat and quenching thirst, palpitations and insomnia. Loss of thirst, spontaneous sweating, chronic diarrhea, neurasthenia and other diseases. Schisandra extract belongs to the astringent medicine of traditional Chinese medicine, and Schisandra extract has a good therapeutic effect on hepatitis. Jiangxiling is widely used in single-flavored Chinese medicine preparations compose...

Claims

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Application Information

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IPC IPC(8): A61K36/57A61K9/08A61K9/10A61K9/14A61K9/20A61K9/48A61P25/24A61K131/00
Inventor 曾建国谢纲王宇虹钟明
Owner 湖南省中药提取工程研究中心有限公司
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