Synthetic method of 2-(2,4- dichlorophenoxy) propionic acid
A technology of dichlorophenoxy and synthesis method, which is applied in the field of intermediates of the agricultural fungicide rice blastamide, can solve problems such as unfavorable popularization and application, discharge of phenol-containing wastewater, and reduce production costs and discharge of phenol-containing wastewater Effect
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Embodiment 1
[0015] In a 1000ml reaction flask equipped with stirring, thermometer and reflux condenser, add 163g (1mol) 2,4-dichlorophenol, 400ml dimethyl sulfoxide, 109g (1mol) 2-chloropropionic acid, 125g (2mol) Potassium hydroxide and 2 g of dimethylaminopyridine were heated to 30°C and stirred for 10 hours. After the reaction, at the bottom temperature of 30°C, sulfuric acid was added dropwise to neutralize, filtered, and the solvent was distilled off under reduced pressure.
[0016] Take 254g of solid matter, add 635g of n-hexane, stir and cool to room temperature, and filter to obtain 227g of product 2-(2,4-dichlorophenoxy)propionic acid with a yield of 93%.
Embodiment 2
[0018] In a 1000ml reaction flask equipped with stirring, thermometer and reflux condenser, add 163g (1mol) 2,4-dichlorophenol, 400ml dimethyl sulfoxide, 109g (1mol) 2-chloropropionic acid, 125g (2mol) Potassium hydroxide and 4 g of dimethylaminopyridine were stirred at 20° C. for 10 hours. After the reaction was completed, sulfuric acid was added dropwise for neutralization, and the mixture was filtered, and the solvent was distilled off under reduced pressure.
[0019] Take 260 g of solid matter, add 780 g of n-hexane, stir and cool to room temperature, and filter to obtain 227 g of product 2-(2,4-dichlorophenoxy)propionic acid with a yield of 93%.
Embodiment 3
[0021] In 1000ml reaction flask equipped with stirring, thermometer and reflux condenser, add 163g (1mol) 2,4-dichlorophenol, 300ml dimethyl sulfoxide, 109g (1mol) 2-chloropropionic acid, 125g (2mol) Potassium hydroxide and 1.5 g of dimethylaminopyridine were stirred at 80° C. for 8 hours. After the reaction, the mixture was kept at 80° C., neutralized by dropwise addition of sulfuric acid, filtered, and the solvent was distilled off under reduced pressure.
[0022] Take 257g of solid matter, add 550g of n-hexane, stir and cool to room temperature, and filter to obtain 225g of product 2-(2,4-dichlorophenoxy)propionic acid with a yield of 93.2%.
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