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Process for extracting chlorogenic acid from Eupatorium adenophorum

A technology for extracting Eupatorium adenophorum and its extraction technology, which is applied in the field of extraction technology of chlorogenic acid in Eupatorium adenophorum, can solve problems such as low yield and waste of resources, and achieve the effect of simple method, low cost and abundant raw materials

Inactive Publication Date: 2008-11-12
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, honeysuckle is mainly used as raw material to extract chlorogenic acid in China, such as the method disclosed in Document 2: Wang Tianzhi, Li Yongmei. Research progress of honeysuckle. West China Pharmaceutical Journal, 2000, 15(4): 292, but the method extracts Only 1% of chlorogenic acid is contained in the honeysuckle, and the yield is low; a large amount of honeysuckle resources are collected, resulting in a waste of resources

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] First crush the tender stems and leaves of Eupatorium adenophorum into powder, then weigh 100 grams of Eupatorium adenophorum tender stems and leaves powder, put it in a round-bottomed flask, add 800 g of 20% (volume ratio) ethanol aqueous solution, and adjust with hydrochloric acid The pH value reached 6; at 80°C, the mixture was refluxed for 2 hours.

[0022] Use a Buchner funnel to filter under reduced pressure, and move the filtrate 1 to an eggplant-shaped bottle; put the filter residue back into the round-bottomed flask, add 800 g of 20% (volume ratio) ethanol water solution again, and adjust the pH value to 6 with hydrochloric acid. ; At 80°C, decoct the mixture for 2 hours.

[0023] Suction filtration under reduced pressure with Buchner funnel again, filter out filtrate 2 and move in the eggplant type bottle; Filter residue is put back in the round bottom flask again, add the ethanol aqueous solution of 800g 20% ​​(volume ratio) again, and adjust the pH value to ...

Embodiment 2

[0027] First crush the tender stems and leaves of Eupatorium adenophorum into powder, then weigh 100 grams of Eupatorium adenophorum leaf powder, put it in a round bottom flask, add 1300 g of 40% (volume ratio) ethanol aqueous solution, and adjust the pH value with hydrochloric acid to 4; at 50°C, decoct the mixture for 5 hours.

[0028] Filter under reduced pressure with a Buchner funnel, and move the filtrate 1 to an eggplant-shaped bottle; put the filter residue back in the round-bottomed flask, add 1300 g of 40% (volume ratio) ethanol aqueous solution again, and adjust the pH value to 4 with hydrochloric acid. ; At 50°C, decoct the mixture for 5 hours.

[0029] Suction filtration under reduced pressure with a Buchner funnel again, and the filtrate 2 is moved to an eggplant-shaped bottle; the filter residue is repacked in a round-bottomed flask, and 1300 g of 40% (volume ratio) ethanol aqueous solution is added again, and the pH value is adjusted to 4; Decoct the mixture f...

Embodiment 3

[0033] First crush the leaves of Eupatorium adenophorum into powder, then weigh 100 grams of Eupatorium adenophorum leaf powder, put it in a round bottom flask, add 1000 g of 60% (volume ratio) ethanol aqueous solution, and adjust the pH value to 2 with hydrochloric acid ; At 60°C, decoct the mixture for 4 hours.

[0034] Use a Buchner funnel to filter under reduced pressure, and move the filtrate 1 to an eggplant-shaped bottle; put the filter residue back into the round-bottomed flask, add 1000 g of 60% (volume ratio) ethanol water solution again, and adjust the pH value to 2 with hydrochloric acid. ; At 60°C, decoct the mixture for 4 hours.

[0035] Suction filtration under reduced pressure with a Buchner funnel again, and the filtrate 2 is moved to an eggplant-shaped bottle; the filter residue is repacked in a round-bottomed flask, and 1000 g of 60% (volume ratio) ethanol aqueous solution is added again, and the pH value is adjusted to 2; Decoct the mixture for 4 hours at ...

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PUM

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Abstract

The invention relates to an extraction process for chlorogenic acid in Eupatorium adenophorum. The method is as follows: the Eupatorium adenophorum is taken as initial raw material, 20 to 60 percent alcohol solution is firstly used to extract, then a product is further purified through macroporous resin, and a chlorogenic acid extract with the content high up to 52.56 percent can be obtained. The method makes up for the limited resource when honeysuckle is take as raw material to extract the chlorogenic acid, can also obtain the chlorogenic acid with high yield when the Eupatorium adenophorum is changed from waste to treasure, has simple method and low cost, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a process for extracting chlorogenic acid from Eupatorium adenophorum. Background technique [0002] Eupatorium adenophorum (Eupatorium adenophorum Spreng) is a perennial herbaceous plant of the genus Eupatorium in the Asteraceae family. It originated in Mexico and was introduced to southern Yunnan from Myanmar and Vietnam around the 1950s. Because of its strong growth and reproductive ability, it has been established in Yunnan The province and its surrounding areas spread. Because of its damage to the ecological environment, it has brought serious harm to agriculture, forestry and animal husbandry. [0003] In view of the fact that Eupatorium adenophorum has become one of the most serious invasive alien species in my country, while strengthening measures to control the spread of Eupatorium adenophorum, researches on its comprehensive utilization have been carried out one after another in an effort to turn harm into wealth. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732C07C67/56A61K36/53
Inventor 曹坳程侯婧吴建平何兰田宇郭美霞
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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