Use of prince feather and fleabane combination in preparing medicament for treating kidney disease

A technology for preparation of Erigeron breviscapus and medicine, which is applied in the direction of drug combination, drug delivery, urinary system diseases, etc., and can solve the problems that are not easy to be strictly distinguished with lower urinary tract inflammation

Inactive Publication Date: 2008-11-19
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally accompanied by lower urinary tract inflammation, it is not easy to strictly distinguish clinically

Method used

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  • Use of prince feather and fleabane combination in preparing medicament for treating kidney disease
  • Use of prince feather and fleabane combination in preparing medicament for treating kidney disease
  • Use of prince feather and fleabane combination in preparing medicament for treating kidney disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Embodiment 1: the preparation of injection

[0110] Raw materials: 7500g of sage, 1500g of escutellaria

[0111] Preparation method: take Chinese sage and add 10 times of water to decoct 3 times, each time for 1 hour, filter, combine the filtrate, concentrate under reduced pressure, add ethanol to make the alcohol content reach 65%, let it stand for 12 hours, suction filter, and take the supernatant liquid, the filtrate was extracted 3 times with ethyl acetate, the ethyl acetate solution was discarded, the aqueous layer was combined, the pH value was adjusted to 3 with hydrochloric acid, the n-butanol saturated with water was extracted 4 times, the n-butanol solution was combined, washed with water, and the Recover n-butanol under pressure, dissolve the residue with 80% ethanol, put it on a polyamide column (500g, Φ8cm, diameter-to-height ratio 1:6, adsorption flow rate 1.5BV / h), collect the flow-through and eluent, and recover ethanol. The residue was vacuum-dried to ...

Embodiment 2

[0115] Embodiment 2: the preparation of tablet

[0116] Raw material: 1000g of Chinese sage, 5000g of escutellaria

[0117] Preparation method: take the sage, add 4 times the amount of water to decoct once, decoct for 0.5 hours, filter, combine the filtrate, concentrate under reduced pressure to a relative density of 1.05 (50°C), add ethanol to make the alcohol content reach 20%, Stir evenly, let stand for 6 hours, filter with suction, recover ethanol from the filtrate under reduced pressure and concentrate to a relative density of 1.04 (50°C), adjust the pH value to 4.7 with saturated sodium carbonate, stir well, let stand for 1 hour, take the supernatant and filter After that, the filtrate was extracted once with 1 / 4 times the amount of ethyl acetate, discarded the ethyl acetate solution, combined the aqueous layer, adjusted the pH value to 1 with hydrochloric acid, and extracted with 1 / 4 times the amount of water-saturated n-butanol Twice, combine the n-butanol solution, w...

Embodiment 3

[0121] Embodiment 3: the preparation of capsule

[0122] Take 100g of Orangus chinensis and 1000g of Erigeron breviscapus, pulverize, mix evenly, decoct with water, filter, and concentrate the filtrate under reduced pressure to form an extract, add conventional excipients for capsules, and prepare capsules according to conventional preparation processes.

[0123] Dosage: Oral: 75mg crude drug / kg body weight / day. It has definite curative effect on kidney disease.

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PUM

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Abstract

The invention discloses the application of the combination of prince feather and fleabane in preparing medicaments for curing kidney diseases. The kidney diseases include nephritis, nephropathy syndrome, chronic renal failure, diabetes, nephropathy, chronic glomerulonephritis and so on. The combination of prince feather and fleabane is prepared as follows: Chinese traditional medicaments, namely prince feather and fleabane, are combined; the combined prince feather and fleaban are extracted, or the prince feather and the fleabane are extracted separately. The invention provides a new medicinal use of the combination of prince feather and fleabane, namely the application of the combination in preparing medicaments for curing kidney diseases. Proven through animal experiments, the combination of the prince feather and the fleabane has true curative effect on cure of kidney diseases, and provides a new medicine for curing kidney diseases and a new option for sufferers.

Description

technical field [0001] The invention relates to the application of the composition in the preparation of medicines, in particular to the application of the composition of sagerae and breviscapine in the preparation of medicines for treating kidney diseases. Background technique [0002] The kidney is an important part of the urinary system, and kidney disease first affects urinary function. Western medicine believes that the kidney is not only a urinary organ, but also has endocrine functions, such as the secretion of erythropoietin and renin, which can promote the conversion of calcitriol, which play a very important role in the human body. Traditional Chinese medicine believes that the kidney not only urinates, but also controls bones and bones, and controls reproduction. Usually, some reproductive system diseases are treated from the kidney to achieve good results. Kidney disease has a high incidence rate and a high disability rate, which poses a serious threat to the he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K9/48A61K9/20A61K9/10A61K9/107A61K9/08A61K9/16A61P13/12
Inventor 窦啟玲周黎亚
Owner GUIZHOU YIBAI PHARMA CO LTD
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