Low virulent strain of porcine reproductive and respiratory syndrome virus, immunogenicity immunogenicity material and vaccine

Abstract

The application relates to a domesticated porcine reproductive and respiratory syndrome virus low virulent strain (JXA1-R strain), immunogenicity substance containing the viral strain, and a porcine reproductive and respiratory syndrome virus low virulent live vaccine developed through making use of the strain. The live vaccine is used to prevent the porcine reproductive and respiratory syndrome,in particular the highly pathogenic blue-ear porcine disease.

Description

technical field [0001] The invention relates to the prevention and control of animal diseases, in particular to an artificial attenuated virus strain of porcine reproductive and respiratory syndrome virus and immunogenic substances and vaccines containing the virus strain. Background technique [0002] Porcine reproductive and respiratory syndrome (also known as porcine blue ear disease) is caused by porcine reproductive and respiratory syndrome virus (porcinereproductive and respiratory syndrome virus, PRRSV), with fever, abortion, and increased mortality of piglets before and after weaning. Diseases with clinical features such as breathing disorder in pigs of different ages. The disease was first discovered in North America in 1987, and almost at the same time, the disease was also reported in Europe. At present, the disease is one of the important diseases seriously affecting the development of the pig industry in the world. [0003] Vaccination is the most effective wa...

AI Technical Summary

Problems solved by technology

[0009] 1. Non-highly pathogenic PRRS virus is generally used as vaccine strain at home and abroad, and the prepared immunogenic substances and vaccines can only resist the attack of highly pathogenic PRRS virus to a certain extent. However, there are differences in the protective effect of products from different manufacturers, and the immune effect is not reliable. It has not been approved by the state to prevent and control the current epidemic of highly pathogenic PRRS.

[0010] 2. The applicant previously prepared immunogenic substances from the highly pathogenic porcine blue-ear disease virus NVDC-JXA1 strain and formulated them into inactivated vaccines, which were designated by the state for the emergency prevention and control of highly pathogenic porcine blue-ear disease in the country. Remarkable results have been achieved, and significant contributions have been made to control the spread of the epidemic, but the disadvantages are: (1) virulent strains can cause disease, and can only be used to produce inactivated immunogenic substances and inactivated vaccines, and cannot be directly administered to pigs (2) Prepare inactivated immunogenic substances and inactivated vaccines with virulent strains, the ability to stimulate the body to produce cellular immune responses is worse than that of live viruses, and the immune efficacy needs to be improved; (3) The production of immunogenic substances and vaccines with virulent strains requires a large amount of virulent cultivation, so the production environment needs to be strictly controlled to prevent the spread of virulent viruses; (4) the cost of preparing inactivated vaccines is much higher than that of attenuated live vaccines

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