Use of pseudo-ginseng saponin component for treating septicemia

A technology of notoginseng saponins and sepsis, which is applied in the application field of notoginseng saponins to treat sepsis, and can solve the problems of increasing the death rate of patients with severe sepsis and not being able to cure sepsis

Active Publication Date: 2008-12-24
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, recent studies have shown that this approach does not cure sepsis and increases mortality in patients with severe sepsis
Thus, finding ways to prevent severe microcirculatory disturbances in LPS-induced sepsis remains a challenge

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] tablet

[0080] [Prescription] Rb1 100g microcrystalline cellulose 50g micronized silica gel 3g magnesium stearate 1.5g

[0081] [Preparation method] Take the raw materials and auxiliary materials and pass them through a 100-mesh sieve; take notoginseng saponins and microcrystalline cellulose, mix well, use 60% ethanol as a binder to make a soft material, pass through a 20-mesh sieve to make granules, and dry at 60°C , take it out, sieve through a 30-mesh sieve for granulation, add micropowder silica gel and magnesium stearate, mix well, press into tablets, and make 1,000 tablets, to obtain.

Embodiment 2

[0083] [Prescription] Rg1 75g Microcrystalline cellulose 37g Micropowder silica gel 2.3g Magnesium stearate 1.1g

[0084] [Preparation method] Take the original and auxiliary materials and pass through a 100-mesh sieve respectively; take notoginseng saponin, calcium sulfate, and microcrystalline cellulose, mix well, use 60% ethanol in an appropriate amount as a binder to make a soft material, pass through a 20-mesh sieve to make granules, Dry at 60°C, take it out, sieve through a 30-mesh sieve for granulation, add appropriate amount of micro-powder silica gel and magnesium stearate, mix well, and press into tablets to make 1000 pieces.

Embodiment 3

[0086] [Prescription] R1 133g microcrystalline cellulose 66g micronized silica gel 4g magnesium stearate 2g

[0087] [Preparation method] Take the original and auxiliary materials and pass through a 100-mesh sieve respectively; take notoginseng saponin, calcium sulfate, and microcrystalline cellulose, mix well, use 60% ethanol in an appropriate amount as a binder to make a soft material, pass through a 20-mesh sieve to make granules, Dry at 60°C, take it out, sieve through a 30-mesh sieve for granulation, add appropriate amount of micro-powder silica gel and magnesium stearate, mix well, and press into tablets to make 1000 pieces.

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PUM

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Abstract

The invention relates to an application of notoginsenoside for treating septicemia, particularly relates to ginsenoside Rb1 which is the effective component of notoginsenoside, and an application of ginsenoside Rb1 and notoginsenoside R1 in treating and/or preventing septicemia.

Description

Technical field: [0001] The invention relates to the new application of traditional Chinese medicine products, in particular to the application of notoginsenoside components Rb1, Rg1 and R1 in treating and / or preventing sepsis. Background technique: [0002] Panax notoginseng (Panax notoginseng, PN) is the air-dried root of the traditional Chinese medicine Panax notoginseng (Burk) F.H.Chen. Panax notoginsenosides (also known as Panax notoginsenosides, English name: Panax Notoginsenosides, PNS) is the main active ingredient of Panax notoginseng, composed of more than 30 different saponins, widely used clinically to treat diseases related to microcirculation disorders , such as cardiovascular disease and liver dysfunction. [0003] Panax notoginseng saponins have been included in the national pharmacopoeia, and corresponding preparations are on the market, such as Xuesaitong for injection. Ginsenoside Rb1, referred to as Rb1 [English name] Ginsenoside Rb1 [chemical name] β-D...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/704A61P7/00A61P31/04
CPCA61K31/704A61K36/258A61P7/00A61P31/04
Inventor 韩晶岩孙凯郭俊王传社刘育英
Owner TIANJIN TASLY PHARMA CO LTD
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