Method and reagent box for predicting dihydrochlorothiazide antihypertensive efficacy

Abstract

The invention discloses a method for predicting the blood pressure reducing effect of hydrochlorothiazide and a kit, belonging to the medical molecular biology field. The method for predicting the blood pressure reducing effect of hydrochlorothiazide is realized by measuring and determining SLC22A6 gene polymorphism site. The method has the advantage of providing scientific basis for the individual therapy of the patient with high blood pressure disease in the real sense.

Description

A method and kit for predicting the antihypertensive efficacy of hydrochlorothiazide technical field The present invention relates to a method and a kit for predicting the antihypertensive curative effect of hydrochlorothiazide, more specifically to the use of SLC22A6 gene polymorphism site in predicting the antihypertensive curative effect of hydrochlorothiazide in hypertension, belonging to field of medical molecular biology. Background technique Hypertension is the largest independent risk factor for many cardiovascular diseases such as coronary heart disease and cerebral apoplexy. It is possible to reach 1.56 billion annually. In China, the prevalence of hypertension is 18.8%, and there are about 160 million hypertensive patients, and the rate of new cases is increasing at a rate of 3.5 million per year. Actively intervening in blood pressure and controlling high blood pressure through treatment can effectively reduce the incidence and death of stroke and heart disea...

AI Technical Summary

Problems solved by technology

If the function of OAT1 is reduced, it will reduce the secretion of hydrochlorothiazide from the blood into the renal tubules, resulting in a decrease in its diuretic and antihypertensive effects

There is currently no report on the polymorphism of SLC22A6 gene in the prediction of drug efficacy in hypertension

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