Preparation method of heavy metal and trace element mass control standard substance in radix paeoniae rubrathe

A standard substance and heavy metal technology, which is applied in the preparation of test samples, testing pharmaceutical preparations, and material inspection products, etc., can solve the problems of restricting the foreign trade of traditional Chinese medicine, large measurement errors, and inaccurate value transfer.

Inactive Publication Date: 2008-12-24
SHANGHAI INST OF MEASUREMENT & TESTING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no standard material for traditional Chinese medicine, including harmful heavy metals and trace elements in Radix Paeoniae Rubra, in fact, the standard materials used in the detection of heavy metals and trace elements in traditional Chinese medicine are all heavy metals and trace elements in the water matrix as standard materials. Due to the difference of the matrix effect, the measurement error is very large, and the transmission of the value is not accurate, which seriously restricts the foreign trade of Chinese medicine in my country.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0004] Example 1: First, according to the 2005 edition Chinese Pharmacopoeia appendix ΠA medicinal material sampling method, Radix Paeoniae Rubra is sampled, the Radix Paeoniae Rubra Radix Radix Paeoniae Rubra that is sampled is washed with tap water and then cleaned with ultrapure water, and naturally dried in the shade to about 80% weight loss, And dry to constant weight at 50~70 ℃, preferably 60 ℃ temperature, drying time is 2~6 hours, preferably 4 hours; order; then, the particle size of Radix Paeoniae Rubra is crushed to 1350 mesh with a jet mill; then, the crushed Radix Paeoniae Rubra is sealed and packaged at 30 g / bottle; finally, the cobalt-60 gamma ray radiation of 6 kGy is used to sterilize Sterilize as per.

Embodiment 2

[0005] Embodiment 2: First, according to the 2005 edition Chinese Pharmacopoeia appendix ∏A medicinal material sampling method, Radix Paeoniae Rubra is sampled, and the Radix Radix Radix Radix Paeoniae Rubra that is sampled is washed with tap water and then cleaned with ultrapure water, and naturally dried in the shade to about 80% of weight loss, And dry to constant weight at 50~70 ℃, preferably 60 ℃ temperature, drying time is 2~6 hours, preferably 4 hours; order; then, the particle size of Radix Paeoniae Rubra is crushed to 700 mesh with a jet mill; then, the crushed Radix Radix Paeoniae Rubra is sealed and packaged at 35 grams per bottle; finally, the cobalt-60 gamma ray radiation of 6kGy is used to sterilize Sterilize as per.

Embodiment 3

[0006] Embodiment 3: First, according to the 2005 edition Chinese Pharmacopoeia appendix ∏A medicinal material sampling method, Radix Paeoniae Rubra is sampled, and the Radix Radix Radix Radix Paeoniae Rubra that is sampled is washed with tap water and then cleaned with ultrapure water, and naturally dried in the shade to about 80% of weight loss, And dry to constant weight at 50~70 ℃, preferably 60 ℃ temperature, drying time is 2~6 hours, preferably 4 hours; order; then, the particle size of Radix Paeoniae Rubra is crushed to 1000 mesh with a jet mill; then, the crushed Radix Paeoniae Rubra is sealed and packaged at 40 g / bottle; finally, the cobalt-60 gamma ray radiation of 6 kGy is used to sterilize Sterilize as per.

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PUM

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Abstract

The invention relates to the field of metrology and measurement standard quantity value transmission technique, in particular to a preparation method which is widely applied to the researching and monitoring on heavy metal and trace element quality control standard matter (standard sample) of red peony root, comprising the steps of: a. fore processing; b. mechanical crushing; c. airflow crushing; d. sealing package; e. germicidal treatment. The invention provides a quantity value transmission way of the heavy metal and trace element in the red peony root, has outstanding effects on the correct evaluation of researching the detection method for heavy metal and trace element in the Chinese traditional medicine and the quality control of the export Chinese traditional medicine, prompting the standardization of the Chinese traditional medicine, ensuring the quantity value traceability, breaking through the green vallum of the export of the Chinese traditional medicine, and developing the national industry, etc., meanwhile, fills up the blank of the red peony root in the field of heavy metal and trace element standard matter of the Chinese traditional medicine, prompts the development of national Chinese traditional medicine on the export trade, and reduces the trade collision after China joins in the WTO.

Description

technical field [0001] The invention relates to the technical field of measurement and test standard quantity transfer technology, in particular to a preparation method of a quality control standard substance (standard sample) widely used in research and monitoring of heavy metals and trace elements in Radix Paeoniae Rubra. Background technique [0002] Radix Paeoniae Rubra is the dried root of Radix Paeoniae Rubra and Chuanchi Radix Paeoniae Rubra. Currently, the market sources mainly rely on wild plants, and the production areas are widely distributed. It is mainly produced in large areas in the three northeastern provinces, Inner Mongolia, Xinjiang, Gansu, Ningxia, and Sichuan. , Guizhou also has output. Radix Paeoniae Rubra is rich in resources, which can expand blood vessel walls and increase coronary blood flow. Since Radix Radix Radix Radix Paeoniae Rubra contains more paeoniflorin, it is an effective drug for treating migraine and headache. Radix Paeoniae Rubra play...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/15G01N1/28
Inventor 王虎杨静崔启明陈黎明吴立敏吴蓉
Owner SHANGHAI INST OF MEASUREMENT & TESTING TECH
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