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Iron liposomes used as iron supplementary and preparation method thereof

An iron supplement and iron fat technology, applied in the field of biological sciences, can solve the problems of no iron liposome reports and the like, and achieve the effects of reducing drug dosage, reducing toxicity, and saving preparation time.

Inactive Publication Date: 2009-01-07
HEBEI NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although liposomes have the above excellent properties as a drug carrier, no relevant reports about iron liposomes (or called liposomal iron) have been found in the existing literature.

Method used

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  • Iron liposomes used as iron supplementary and preparation method thereof
  • Iron liposomes used as iron supplementary and preparation method thereof
  • Iron liposomes used as iron supplementary and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0029] Composition of iron liposomes:

[0030] The mass ratio of heme iron and / or inorganic iron: cholesterol: lecithin is (0.1-200): (1-10): (10-100).

[0031] Preparation:

[0032]The phospholipids and cholesterol with a weight ratio of (1-10): (10-100) are weighed and completely dissolved in the organic solvent ethanol at a constant temperature of 25-38°C. At the same time, weigh heme iron and / or inorganic iron according to the mass ratio of heme iron and / or inorganic iron: cholesterol: lecithin (0.1~200): (1~10): (10~100), and dissolve them completely In PBS, wherein, lecithin:PBS solid-liquid ratio is 1:15, and the pH value of PBS is 6.5~7.5, obtains PBS iron solution. Slowly drop the completely dissolved phospholipid-cholesterol solution into the high-speed rotating PBS iron solution at 45-50°C, then stir at a constant temperature at 45-50°C or rotary evaporate for 2-5 hours to fully volatilize the ethanol and obtain a uniform Creamy liposomal suspension. Disperse th...

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Abstract

The invention relates to an iron supplement, which is an iron liposome made by ethanol injection. The iron liposome comprises (by weigh parts) heme iron and / or inorganic iron 0.1-200, cholesterol 1-10 and lecithin 10-100; and is prepared by dispersing lecithin and cholesterol ethanol solution into a PBS-containing iron solution under specific conditions. The inventive iron liposome has no toxicity and immunogenicity, has targeting property, and can be used as a drug carrier. The iron liposome can be used in clinics for reducing drug dosage, improving absorption efficiency, reducing toxicity, remarkably improving solubility and stability of the heme iron, and improving bioavailability. The inventive preparation method can form stable liposome with high entrapment efficiency, can effectively save liposome preparation time and simplify preparation process, and has the advantages relatively low requirements on process conditions, easy control, and simple operation.

Description

technical field [0001] The invention relates to a new iron supplement, in particular to iron liposome and a preparation method thereof, belonging to the technical field of biological science. Background technique [0002] Iron-deficiency anemia is one of the most common diseases in my country and the world. There are various kinds of medicines and nutrients for iron supplementation. However, since the absorption mechanism of intestinal iron has not been elucidated, people have developed a variety of Iron supplements have a great blindness, the effect is not ideal, and some are also very toxic, poor in taste and irritating to the digestive tract. With the understanding of intestinal iron absorption mechanism in recent years, we know the intestinal iron absorption mechanism and regulation pathway, which provides a theoretical basis for the development and production of new iron supplements. Heme iron is a kind of biological iron. Compared with other iron supplements, heme iron...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K9/127A61K47/28A61K47/24A61P3/02A61K31/555
Inventor 常彦忠葛兰段相林
Owner HEBEI NORMAL UNIV
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