Temperature sensing in situ gel rubber formulations capable of being injected, preparation method and uses thereof

An in-situ gel and preparation technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of paclitaxel injection application limitations, severe side effects, and vasodilation. Achieve the effect of improving medication compliance, high practicability, and maintaining long-term effects

Inactive Publication Date: 2010-12-01
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

CremophorEL has been proven to have relatively large toxic and side effects. After intravenous administration to dogs, it will cause vasodilation, dyspnea, lethargy, hypotension and death. Moreover, the solvent has hypersensitivity to blood vessels, which makes the clinical application of paclitaxel injection limited. many restrictions
Similarly, docetaxel (Taxotere) injection contains polysorbate-80 (Tween-80) as a solubilizer, and intravenous injection may also produce reactions such as hemolysis

Method used

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  • Temperature sensing in situ gel rubber formulations capable of being injected, preparation method and uses thereof
  • Temperature sensing in situ gel rubber formulations capable of being injected, preparation method and uses thereof
  • Temperature sensing in situ gel rubber formulations capable of being injected, preparation method and uses thereof

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Abstract

The invention relates to injectable temperature sensitive in situ gel preparation and a preparation method as well as an application thereof. The components of the preparation of the invention comprise 0.01 percent to 10 percent of anticancer drugs, 15 percent to 25 percent of pluronic F127, 0.01 percent to 20 percent tween and 45 percent to 84.98 percent of water or buffer solution.

Description

A kind of injectable thermosensitive in situ gel preparation, their preparation method and application Technical field: The invention relates to an injectable pharmaceutical preparation and a preparation method thereof, in particular to an injectable temperature-sensitive in-situ gel preparation, their preparation method and their application in clinical tumor treatment. Background technique: In recent years, the sustained and controlled release injection drug delivery system has attracted the attention of many pharmaceutical researchers and has become a research hotspot in injection drug delivery. Emulsions, liposomes, biodegradable microspheres, and micelles have all been used in the research of injectable drug delivery systems, but they all have stability problems to varying degrees. In addition, liposomes are eliminated quickly in the body and have problems such as sterilization and low drug encapsulation efficiency. The process required to prepare sterile and reproduc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K45/00A61K47/34A61K31/704A61K31/337A61K31/4745A61K31/475A61K33/24A61P35/00A61K47/26
Inventor 张强王坚成张烜杨杨刘瑜
Owner PEKING UNIV
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